Tumour microenvironment responsive nanoconstructs for cancer theranostic

Gulzar, A; Xu, J; Wang, C; He, F; Yang, D; Gai, S; Yang, P; Lin, J; Jin, D; Xing, B

Tumour microenvironment responsive nanoconstructs for cancer theranostic

Gulzar, A Xu, J Wang, C He, F Yang, D Gai, S Yang, P Lin, J Jin, D

Xing, B

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Publication Type:: Journal Article
Citation:: Nano Today, 2019, 26 pp. 16 - 56
Issue Date:: 2019-06-01

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Field	Value	Language
dc.contributor.author	Gulzar, A	en_US
dc.contributor.author	Xu, J	en_US
dc.contributor.author	Wang, C	en_US
dc.contributor.author	He, F	en_US
dc.contributor.author	Yang, D	en_US
dc.contributor.author	Gai, S	en_US
dc.contributor.author	Yang, P	en_US
dc.contributor.author	Lin, J	en_US
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666	en_US
dc.contributor.author	Xing, B	en_US
dc.date.issued	2019-06-01	en_US
dc.identifier.citation	Nano Today, 2019, 26 pp. 16 - 56	en_US
dc.identifier.issn	1748-0132	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136623
dc.description.abstract	© 2019 Elsevier Ltd The tumour mass is made up of not only of a heterogeneous population of cancer cells nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors besides extracellular matrix proteins, together recognized as the tumour microenvironment (TME). Tumour development is overwhelmingly affected through the dealings of cancer cells with their environment which eventually conclude whether the primary tumour is eliminated, metastasizes or creates dormant micro metastases. The TME may perhaps shape therapeutic responses as well as resistance. Some inimitable features of TME, for example vascular abnormalities, hypoxia, acidic pH and glutathione (GSH) are comparative to normal tissue. Several types of cells, together with tumour cells, macrophages, immune and fibroblast cells are nourished by flawed blood vessels in the solid tumour. To dispense anticancer agents to tumour sites nanovehicles can be competent carts. For augmented therapeutic efficacy, TME is the key for designing of nanoparticles (NPs). In this review, we will discuss the TME and summarize the current advancement in several nano-formulations for cancer therapy, with an extraordinary stress on TME-responsive ones. Scheme 1 highlights several TME modulation tactics with positive cancer therapeutic competence. The design of nanoconstructs and future challenges, consideration and opportunities are also discussed in detail. We have confidence in that these modulation approaches of TME tender a reliable opportunity for the practical translation of nanoparticle formulas into clinic.	en_US
dc.relation.ispartof	Nano Today	en_US
dc.relation.isbasedon	10.1016/j.nantod.2019.03.007	en_US
dc.subject.classification	Nanoscience & Nanotechnology	en_US
dc.title	Tumour microenvironment responsive nanoconstructs for cancer theranostic	en_US
dc.type	Journal Article
utslib.citation.volume	26	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
utslib.for	1007 Nanotechnology	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	26	en_US

Abstract:

© 2019 Elsevier Ltd The tumour mass is made up of not only of a heterogeneous population of cancer cells nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors besides extracellular matrix proteins, together recognized as the tumour microenvironment (TME). Tumour development is overwhelmingly affected through the dealings of cancer cells with their environment which eventually conclude whether the primary tumour is eliminated, metastasizes or creates dormant micro metastases. The TME may perhaps shape therapeutic responses as well as resistance. Some inimitable features of TME, for example vascular abnormalities, hypoxia, acidic pH and glutathione (GSH) are comparative to normal tissue. Several types of cells, together with tumour cells, macrophages, immune and fibroblast cells are nourished by flawed blood vessels in the solid tumour. To dispense anticancer agents to tumour sites nanovehicles can be competent carts. For augmented therapeutic efficacy, TME is the key for designing of nanoparticles (NPs). In this review, we will discuss the TME and summarize the current advancement in several nano-formulations for cancer therapy, with an extraordinary stress on TME-responsive ones. Scheme 1 highlights several TME modulation tactics with positive cancer therapeutic competence. The design of nanoconstructs and future challenges, consideration and opportunities are also discussed in detail. We have confidence in that these modulation approaches of TME tender a reliable opportunity for the practical translation of nanoparticle formulas into clinic.

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http://hdl.handle.net/10453/136623