Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer's disease etiology

Woods, JJ; Skelding, KA; Martin, KL; Aryal, R; Sontag, E; Johnstone, DM; Horvat, JC; Hansbro, PM; Milward, EA

Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer's disease etiology

Woods, JJ Skelding, KA Martin, KL Aryal, R Sontag, E Johnstone, DM Horvat, JC Hansbro, PM

Milward, EA

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Publication Type:: Journal Article
Citation:: Brain, Behavior, and Immunity, 2020, 83 pp. 22 - 32
Issue Date:: 2020-01-01

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Field	Value	Language
dc.contributor.author	Woods, JJ	en_US
dc.contributor.author	Skelding, KA	en_US
dc.contributor.author	Martin, KL	en_US
dc.contributor.author	Aryal, R	en_US
dc.contributor.author	Sontag, E	en_US
dc.contributor.author	Johnstone, DM	en_US
dc.contributor.author	Horvat, JC	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.contributor.author	Milward, EA	en_US
dc.date.available	2019-10-14	en_US
dc.date.issued	2020-01-01	en_US
dc.identifier.citation	Brain, Behavior, and Immunity, 2020, 83 pp. 22 - 32	en_US
dc.identifier.issn	0889-1591	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136755
dc.description.abstract	© 2019 Elsevier Inc. Alzheimer's disease, the most common form of dementia, was first formally described in 1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of the brain immune response have revived longstanding contention about the possibility of causal relationships between brain pathogens and Alzheimer's disease. Research has focused on infectious pathogens that may colonize the brain such as herpes simplex type I. Some researchers have proposed the respiratory bacteria Chlamydia pneumoniae may also be implicated in Alzheimer's disease, however this remains controversial. This review aims to provide a balanced overview of the current evidence and its limitations and future approaches that may resolve controversies. We discuss the evidence from in vitro, animal and human studies proposed to implicate Chlamydia pneumoniae in Alzheimer's disease and other neurological conditions, the potential mechanisms by which the bacterium may contribute to pathogenesis and limitations of previous studies that may explain the inconsistencies in the literature.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1079187
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation.ispartof	Brain, Behavior, and Immunity	en_US
dc.relation.isbasedon	10.1016/j.bbi.2019.10.014	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.title	Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer's disease etiology	en_US
dc.type	Journal Article
utslib.citation.volume	83	en_US
utslib.for	1107 Immunology	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1701 Psychology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	83	en_US

Abstract:

© 2019 Elsevier Inc. Alzheimer's disease, the most common form of dementia, was first formally described in 1907 yet its etiology has remained elusive. Recent proposals that Aβ peptide may be part of the brain immune response have revived longstanding contention about the possibility of causal relationships between brain pathogens and Alzheimer's disease. Research has focused on infectious pathogens that may colonize the brain such as herpes simplex type I. Some researchers have proposed the respiratory bacteria Chlamydia pneumoniae may also be implicated in Alzheimer's disease, however this remains controversial. This review aims to provide a balanced overview of the current evidence and its limitations and future approaches that may resolve controversies. We discuss the evidence from in vitro, animal and human studies proposed to implicate Chlamydia pneumoniae in Alzheimer's disease and other neurological conditions, the potential mechanisms by which the bacterium may contribute to pathogenesis and limitations of previous studies that may explain the inconsistencies in the literature.

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http://hdl.handle.net/10453/136755