Brillouin imaging for studies of micromechanics in biology and biomedicine: from current state-of-the-art to future clinical translation

Poon, C; Chou, J; Cortie, M; Kabakova, I

Brillouin imaging for studies of micromechanics in biology and biomedicine: from current state-of-the-art to future clinical translation

Poon, C Chou, J Cortie, M Kabakova, I

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Field	Value	Language
dc.contributor.author	Poon, C	en_US
dc.contributor.author	Chou, J	en_US
dc.contributor.author	Cortie, M	en_US
dc.contributor.author	Kabakova, I https://orcid.org/0000-0002-6831-9478	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138204
dc.description.abstract	Brillouin imaging is increasingly recognized to be a powerful technique that enables non-invasive measurement of the mechanical properties of cells and tissues on a microscopic scale. This provides an unprecedented tool for investigating cell mechanobiology, cell-matrix interactions, tissue biomechanics in healthy and disease conditions and other fundamental biological questions. Recent advances in optical hardware have particularly accelerated the development of the technique, with increasingly finer spectral resolution and more powerful system capabilities. We envision that further developments will enable translation of Brillouin imaging to assess clinical specimens and samples for disease screening and monitoring. The purpose of this review is to summarize the state-of-the-art in Brillouin microscopy and imaging with a specific focus on biological tissue and cell measurements. Key system and operational requirements will be discussed to facilitate wider application of Brillouin imaging along with current challenges for translation of the technology for clinical and medical applications.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DP190101973
dc.title	Brillouin imaging for studies of micromechanics in biology and biomedicine: from current state-of-the-art to future clinical translation	en_US
dc.type	Journal Article
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	open_access

Abstract:

Brillouin imaging is increasingly recognized to be a powerful technique that enables non-invasive measurement of the mechanical properties of cells and tissues on a microscopic scale. This provides an unprecedented tool for investigating cell mechanobiology, cell-matrix interactions, tissue biomechanics in healthy and disease conditions and other fundamental biological questions. Recent advances in optical hardware have particularly accelerated the development of the technique, with increasingly finer spectral resolution and more powerful system capabilities. We envision that further developments will enable translation of Brillouin imaging to assess clinical specimens and samples for disease screening and monitoring. The purpose of this review is to summarize the state-of-the-art in Brillouin microscopy and imaging with a specific focus on biological tissue and cell measurements. Key system and operational requirements will be discussed to facilitate wider application of Brillouin imaging along with current challenges for translation of the technology for clinical and medical applications.

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http://hdl.handle.net/10453/138204