Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease.

Panth, N; Paudel, KR; Parajuli, K

Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease.

Panth, N

Paudel, KR

Parajuli, K

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Publication Type:: Journal Article
Citation:: Adv Med, 2016, 2016 pp. 9152732 - ?
Issue Date:: 2016

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Field	Value	Language
dc.contributor.author	Panth, N https://orcid.org/0000-0003-0860-6800	en_US
dc.contributor.author	Paudel, KR https://orcid.org/0000-0002-3591-2080	en_US
dc.contributor.author	Parajuli, K https://orcid.org/0000-0002-5968-4051	en_US
dc.date.available	2016-08-24	en_US
dc.date.issued	2016	en_US
dc.identifier.citation	Adv Med, 2016, 2016 pp. 9152732 - ?	en_US
dc.identifier.issn	2356-6752	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138438
dc.description.abstract	Cardiovascular diseases (CVDs) have been the prime cause of mortality worldwide for decades. However, the underlying mechanism of their pathogenesis is not fully clear yet. It has been already established that reactive oxygen species (ROS) play a vital role in the progression of CVDs. ROS are chemically unstable reactive free radicals containing oxygen, normally produced by xanthine oxidase, nicotinamide adenine dinucleotide phosphate oxidase, lipoxygenases, or mitochondria or due to the uncoupling of nitric oxide synthase in vascular cells. When the equilibrium between production of free radicals and antioxidant capacity of human physiology gets altered due to several pathophysiological conditions, oxidative stress is induced, which in turn leads to tissue injury. This review focuses on pathways behind the production of ROS, its involvement in various intracellular signaling cascades leading to several cardiovascular disorders (endothelial dysfunction, ischemia-reperfusion, and atherosclerosis), methods for its detection, and therapeutic strategies for treatment of CVDs targeting the sources of ROS. The information generated by this review aims to provide updated insights into the understanding of the mechanisms behind cardiovascular complications mediated by ROS.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Adv Med	en_US
dc.relation.isbasedon	10.1155/2016/9152732	en_US
dc.title	Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease.	en_US
dc.type	Journal Article
utslib.citation.volume	2016	en_US
utslib.location.activity	United States	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	2016	en_US

Abstract:

Cardiovascular diseases (CVDs) have been the prime cause of mortality worldwide for decades. However, the underlying mechanism of their pathogenesis is not fully clear yet. It has been already established that reactive oxygen species (ROS) play a vital role in the progression of CVDs. ROS are chemically unstable reactive free radicals containing oxygen, normally produced by xanthine oxidase, nicotinamide adenine dinucleotide phosphate oxidase, lipoxygenases, or mitochondria or due to the uncoupling of nitric oxide synthase in vascular cells. When the equilibrium between production of free radicals and antioxidant capacity of human physiology gets altered due to several pathophysiological conditions, oxidative stress is induced, which in turn leads to tissue injury. This review focuses on pathways behind the production of ROS, its involvement in various intracellular signaling cascades leading to several cardiovascular disorders (endothelial dysfunction, ischemia-reperfusion, and atherosclerosis), methods for its detection, and therapeutic strategies for treatment of CVDs targeting the sources of ROS. The information generated by this review aims to provide updated insights into the understanding of the mechanisms behind cardiovascular complications mediated by ROS.

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http://hdl.handle.net/10453/138438