Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases

Tew, XN; Xin Lau, NJ; Chellappan, DK; Madheswaran, T; Zeeshan, F; Tambuwala, MM; Aljabali, AA; Balusamy, SR; Perumalsamy, H; Gupta, G; Oliver, BG; Hsu, A; Wark, P; Reddy, K; Wadhwa, R; Hansbro, PM; Dua, K

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases

Tew, XN Xin Lau, NJ Chellappan, DK Madheswaran, T Zeeshan, F Tambuwala, MM Aljabali, AA Balusamy, SR Perumalsamy, H Gupta, G Oliver, BG

Hsu, A Wark, P Reddy, K Wadhwa, R Hansbro, PM

Dua, K

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Publication Type:: Journal Article
Citation:: Chemico-Biological Interactions, 2020, 317
Issue Date:: 2020-02-01

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Field	Value	Language
dc.contributor.author	Tew, XN	en_US
dc.contributor.author	Xin Lau, NJ	en_US
dc.contributor.author	Chellappan, DK	en_US
dc.contributor.author	Madheswaran, T	en_US
dc.contributor.author	Zeeshan, F	en_US
dc.contributor.author	Tambuwala, MM	en_US
dc.contributor.author	Aljabali, AA	en_US
dc.contributor.author	Balusamy, SR	en_US
dc.contributor.author	Perumalsamy, H	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	Oliver, BG https://orcid.org/0000-0002-7122-9262	en_US
dc.contributor.author	Hsu, A	en_US
dc.contributor.author	Wark, P	en_US
dc.contributor.author	Reddy, K	en_US
dc.contributor.author	Wadhwa, R	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.date.available	2020-01-16	en_US
dc.date.issued	2020-02-01	en_US
dc.identifier.citation	Chemico-Biological Interactions, 2020, 317	en_US
dc.identifier.issn	0009-2797	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138455
dc.description.abstract	© 2020 Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory diseases.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1156589
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1079187
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1156589
dc.relation.ispartof	Chemico-Biological Interactions	en_US
dc.relation.isbasedon	10.1016/j.cbi.2020.108947	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Respiratory Tract Diseases	en_US
dc.subject.mesh	Chronic Disease	en_US
dc.subject.mesh	Inflammation	en_US
dc.subject.mesh	Berberine	en_US
dc.subject.mesh	Anti-Inflammatory Agents	en_US
dc.subject.mesh	Gene Expression Regulation	en_US
dc.title	Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases	en_US
dc.type	Journal Article
utslib.citation.volume	317	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	317	en_US

Abstract:

© 2020 Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory diseases.

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http://hdl.handle.net/10453/138455