Cytotoxic factor influencing acquired antimicrobial resistance in Pseudomonas aeruginosa

Subedi, D; Vijay, AK; Rice, SA; Willcox, M

Cytotoxic factor influencing acquired antimicrobial resistance in Pseudomonas aeruginosa

Subedi, D Vijay, AK Rice, SA

Willcox, M

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Publication Type:: Journal Article
Citation:: Microbiology Australia, 2019, 40 (4), pp. 161 - 164
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Subedi, D	en_US
dc.contributor.author	Vijay, AK	en_US
dc.contributor.author	Rice, SA https://orcid.org/0000-0002-9486-2343	en_US
dc.contributor.author	Willcox, M	en_US
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	Microbiology Australia, 2019, 40 (4), pp. 161 - 164	en_US
dc.identifier.issn	1324-4272	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138613
dc.description.abstract	© 2019 CSIRO. All rights reserved. The Gram-negative opportunistic bacterium Pseudomonas aeruginosa is associated with different types of human infections and because of emerging multidrug-resistant strains, these infections are of major global public health concern. Certain strains possess a unique cytotoxic effector protein ExoU, which contributes to the fitness of this organism in different ecological niches and is associated with acquired antibiotic resistance. This article summarises the current knowledge of the exoU gene in P. aeruginosa, including genetics, distribution in strains from different locations and association with antibiotic resistance. Understanding of this effector protein may have important implications for the understanding of pathogenesis and antimicrobial resistance in P. aeruginosa infections.	en_US
dc.relation.ispartof	Microbiology Australia	en_US
dc.relation.isbasedon	10.1071/MA19048	en_US
dc.title	Cytotoxic factor influencing acquired antimicrobial resistance in Pseudomonas aeruginosa	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	40	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	40	en_US

Abstract:

© 2019 CSIRO. All rights reserved. The Gram-negative opportunistic bacterium Pseudomonas aeruginosa is associated with different types of human infections and because of emerging multidrug-resistant strains, these infections are of major global public health concern. Certain strains possess a unique cytotoxic effector protein ExoU, which contributes to the fitness of this organism in different ecological niches and is associated with acquired antibiotic resistance. This article summarises the current knowledge of the exoU gene in P. aeruginosa, including genetics, distribution in strains from different locations and association with antibiotic resistance. Understanding of this effector protein may have important implications for the understanding of pathogenesis and antimicrobial resistance in P. aeruginosa infections.

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http://hdl.handle.net/10453/138613