The role of the free beta subunit of human chorionic gonadotropin in human malignancy

Sinnappan, S; Baxter, R; Marsh, D

The role of the free beta subunit of human chorionic gonadotropin in human malignancy

Sinnappan, S Baxter, R Marsh, D

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Publisher:: Elsevier
Publication Type:: Chapter
Citation:: 100 Years of Human Chorionic Gonadotropin Reviews and New Perspectives, 2020, 1
Issue Date:: 2020-01-01

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Field	Value	Language
dc.contributor.author	Sinnappan, S	en_US
dc.contributor.author	Baxter, R	en_US
dc.contributor.author	Marsh, D https://orcid.org/0000-0001-5899-4931	en_US
dc.contributor.editor	Cole, L	en_US
dc.contributor.editor	Butler, S	en_US
dc.date.issued	2020-01-01	en_US
dc.identifier.citation	100 Years of Human Chorionic Gonadotropin Reviews and New Perspectives, 2020, 1	en_US
dc.identifier.isbn	0128200502	en_US
dc.identifier.isbn	9780128200506	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138857
dc.description.abstract	Detection of an elevated level of placental derived β-subunit of human chorionic gonadotropin hormone (hCGβ) in blood or urine is used clinically for the confirmation of pregnancy. Ectopic production of hCGβ is also seen in some cancers where it can be associated with aggressive and metastatic disease, as well as resistance to radiotherapy and chemotherapy. Measurement of hCGβ, or its metabolic product β-core fragment, in serum, ascites, urine and tumour tissue, shows potential as a diagnostic and/or prognostic biomarker for some cancers. Studies in model systems have shown that elevated levels of hCGβ may increase the tumorigenic behaviour of cells by activating oncogenes and increasing proliferation, migration and invasion. The potential tumorigenic role of ectopic hCGβ has identified it as an immunotherapy target for some non-trophoblastic cancers. We discuss cancer-associated functions of hCGβ, its value as a biomarker for diagnosis, management and prognosis, and its potential as a therapeutic target.	en_US
dc.publisher	Elsevier	en_US
dc.relation.ispartof	100 Years of Human Chorionic Gonadotropin Reviews and New Perspectives	en_US
dc.title	The role of the free beta subunit of human chorionic gonadotropin in human malignancy	en_US
dc.type	Chapter
utslib.citation.edition	1	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.consider-herdc	false	en_US
pubs.edition	1	en_US
pubs.publication-status	Accepted	en_US

Abstract:

Detection of an elevated level of placental derived β-subunit of human chorionic gonadotropin hormone (hCGβ) in blood or urine is used clinically for the confirmation of pregnancy. Ectopic production of hCGβ is also seen in some cancers where it can be associated with aggressive and metastatic disease, as well as resistance to radiotherapy and chemotherapy. Measurement of hCGβ, or its metabolic product β-core fragment, in serum, ascites, urine and tumour tissue, shows potential as a diagnostic and/or prognostic biomarker for some cancers. Studies in model systems have shown that elevated levels of hCGβ may increase the tumorigenic behaviour of cells by activating oncogenes and increasing proliferation, migration and invasion. The potential tumorigenic role of ectopic hCGβ has identified it as an immunotherapy target for some non-trophoblastic cancers. We discuss cancer-associated functions of hCGβ, its value as a biomarker for diagnosis, management and prognosis, and its potential as a therapeutic target.

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http://hdl.handle.net/10453/138857