Investigating the mechanisms of acupuncture on neural excitability in healthy adults.

McCambridge, AB; Zaslawski, C; Bradnam, LV

Investigating the mechanisms of acupuncture on neural excitability in healthy adults.

McCambridge, AB Zaslawski, C

Bradnam, LV

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Publisher:: Lippincott, Williams & Wilkins
Publication Type:: Journal Article
Citation:: NeuroReport, 2019, 30, (2), pp. 71-76
Issue Date:: 2019-01

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Field	Value	Language
dc.contributor.author	McCambridge, AB
dc.contributor.author	Zaslawski, C https://orcid.org/0000-0001-5618-5161
dc.contributor.author	Bradnam, LV
dc.date.accessioned	2020-05-01T09:08:02Z
dc.date.available	2020-05-01T09:08:02Z
dc.date.issued	2019-01
dc.identifier.citation	NeuroReport, 2019, 30, (2), pp. 71-76
dc.identifier.issn	0959-4965
dc.identifier.issn	1473-558X
dc.identifier.uri	http://hdl.handle.net/10453/140388
dc.description.abstract	Acupuncture is gaining interest as a potential treatment modality for various neurological conditions. Yet, the underlying mechanisms and efficacy on brain function are not well understood. Therefore, this study investigated the previously proposed hypothesis that acupuncture suppresses motor cortex excitability using transcranial magnetic stimulation (TMS) in healthy adults. The study was randomised, sham-controlled, and double-blinded. Single and paired-pulse TMS was delivered before, during, immediately after, and 30 min after removal of the needle. Acupuncture to the right Hegu acupoint (LI-4) of the hand was delivered by an experienced acupuncturist using standardised manipulations. A disposable (0.22×30 mm, Hwato) needle was used for verum stimulation (penetrating) and a Park retractable needle for sham (nonpenetrating). The peak-to-peak amplitude of TMS-induced motor-evoked potentials was recorded from two intrinsic hand muscles. Needling sensations were quantified using the Massachusett's acupuncture sensation scale. Participant needling sensations were not different between verum or sham acupuncture (P>0.54). Corticomotor excitability, intracortical inhibition, and intracortical facilitation were not modulated by verum or sham acupuncture during, immediately after, or 30 min after, recorded from a local or distant hand muscle to the needling site (all P>0.075). Contrary to previous studies, manual acupuncture did not affect motor cortex excitability in healthy adults. Because of the increasing popularity of acupuncture therapy, further research using patient populations should be considered.
dc.format	Print
dc.language	eng
dc.publisher	Lippincott, Williams & Wilkins
dc.relation.ispartof	NeuroReport
dc.relation.isbasedon	10.1097/wnr.0000000000001159
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1109 Neurosciences, 1702 Cognitive Sciences
dc.subject.classification	Neurology & Neurosurgery
dc.subject.mesh	Motor Cortex
dc.subject.mesh	Humans
dc.subject.mesh	Acupuncture Therapy
dc.subject.mesh	Cross-Over Studies
dc.subject.mesh	Double-Blind Method
dc.subject.mesh	Evoked Potentials, Motor
dc.subject.mesh	Adult
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Transcranial Magnetic Stimulation
dc.subject.mesh	Young Adult
dc.subject.mesh	Healthy Volunteers
dc.subject.mesh	Acupuncture Therapy
dc.subject.mesh	Adult
dc.subject.mesh	Cross-Over Studies
dc.subject.mesh	Double-Blind Method
dc.subject.mesh	Evoked Potentials, Motor
dc.subject.mesh	Female
dc.subject.mesh	Healthy Volunteers
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Motor Cortex
dc.subject.mesh	Transcranial Magnetic Stimulation
dc.subject.mesh	Young Adult
dc.title	Investigating the mechanisms of acupuncture on neural excitability in healthy adults.
dc.type	Journal Article
utslib.citation.volume	30
utslib.location.activity	England
utslib.for	1109 Neurosciences
utslib.for	1702 Cognitive Sciences
utslib.for	1109 Neurosciences
utslib.for	1702 Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-05-01T09:07:58Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	30
utslib.start-page	71
utslib.citation.issue	2

Abstract:

Acupuncture is gaining interest as a potential treatment modality for various neurological conditions. Yet, the underlying mechanisms and efficacy on brain function are not well understood. Therefore, this study investigated the previously proposed hypothesis that acupuncture suppresses motor cortex excitability using transcranial magnetic stimulation (TMS) in healthy adults. The study was randomised, sham-controlled, and double-blinded. Single and paired-pulse TMS was delivered before, during, immediately after, and 30 min after removal of the needle. Acupuncture to the right Hegu acupoint (LI-4) of the hand was delivered by an experienced acupuncturist using standardised manipulations. A disposable (0.22×30 mm, Hwato) needle was used for verum stimulation (penetrating) and a Park retractable needle for sham (nonpenetrating). The peak-to-peak amplitude of TMS-induced motor-evoked potentials was recorded from two intrinsic hand muscles. Needling sensations were quantified using the Massachusett's acupuncture sensation scale. Participant needling sensations were not different between verum or sham acupuncture (P>0.54). Corticomotor excitability, intracortical inhibition, and intracortical facilitation were not modulated by verum or sham acupuncture during, immediately after, or 30 min after, recorded from a local or distant hand muscle to the needling site (all P>0.075). Contrary to previous studies, manual acupuncture did not affect motor cortex excitability in healthy adults. Because of the increasing popularity of acupuncture therapy, further research using patient populations should be considered.

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http://hdl.handle.net/10453/140388