AIEgen based poly(L-lactic-co-glycolic acid) magnetic nanoparticles to localize cytokine VEGF for early cancer diagnosis and photothermal therapy

Ma, K; Liu, GJ; Yan, L; Wen, S; Xu, B; Tian, W; Goldys, EM; Liu, G

AIEgen based poly(L-lactic-co-glycolic acid) magnetic nanoparticles to localize cytokine VEGF for early cancer diagnosis and photothermal therapy

Ma, K Liu, GJ Yan, L Wen, S

Xu, B Tian, W Goldys, EM Liu, G

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Publisher:: FUTURE MEDICINE LTD
Publication Type:: Journal Article
Citation:: Nanomedicine, 2019, 14, (9), pp. 1191-1201
Issue Date:: 2019-05-01

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Field	Value	Language
dc.contributor.author	Ma, K
dc.contributor.author	Liu, GJ
dc.contributor.author	Yan, L
dc.contributor.author	Wen, S https://orcid.org/0000-0002-4670-4658
dc.contributor.author	Xu, B
dc.contributor.author	Tian, W
dc.contributor.author	Goldys, EM
dc.contributor.author	Liu, G
dc.date.accessioned	2020-05-03T21:25:32Z
dc.date.available	2020-05-03T21:25:32Z
dc.date.issued	2019-05-01
dc.identifier.citation	Nanomedicine, 2019, 14, (9), pp. 1191-1201
dc.identifier.issn	1743-5889
dc.identifier.issn	1748-6963
dc.identifier.uri	http://hdl.handle.net/10453/140424
dc.description.abstract	© 2019 2019 Future Medicine Ltd. Aim: We demonstrated a novel theranostic system for simultaneous photothermal therapy and magnetic resonance imaging applicable to early diagnostics and treatment of cancer cells. Materials & methods: Oleic acid-Fe3O4 and triphenylamine-divinylanthracene-dicyano were loaded to the poly(L-lactic-co-glycolic acid) nanoparticles (NPs) on which anti-VEGF antibodies were modified to form anti-VEGF/OA-Fe3O4/triphenylamine-divinylanthracene-dicyano@poly(L-lactic-co-glycolic acid) NPs. The 1H nuclear magnetic resonance (NMR), mass spectra, fluorescence, UV absorption, dynamic light scattering, transmission electron microscope and inductively coupled plasma mass spectrometry tests were used to characterize the NPs, and the bioimaging was illustrated by confocal laser scanning microscope (CLSM) and in vivo MRI animal experiment. Results: This system was capable to recognize the overexpressed VEGF-A as low as 68 pg/ml in different cell lines with good selectivity and photothermal therapy effect. Conclusion: These ultrasensitive theranostic NPs were able to identify tumor cells by fluorescence imaging and MRI, and destroy tumors under near infrared illumination.
dc.language	English
dc.publisher	FUTURE MEDICINE LTD
dc.relation.ispartof	Nanomedicine
dc.relation.isbasedon	10.2217/nnm-2018-0467
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	0306 Physical Chemistry (incl. Structural), 1004 Medical Biotechnology, 1007 Nanotechnology
dc.subject.classification	Nanoscience & Nanotechnology
dc.title	AIEgen based poly(L-lactic-co-glycolic acid) magnetic nanoparticles to localize cytokine VEGF for early cancer diagnosis and photothermal therapy
dc.type	Journal Article
utslib.citation.volume	14
utslib.for	0306 Physical Chemistry (incl. Structural)
utslib.for	1004 Medical Biotechnology
utslib.for	1007 Nanotechnology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2020-05-03T21:25:28Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	14
utslib.start-page	1191
utslib.citation.issue	9

Abstract:

© 2019 2019 Future Medicine Ltd. Aim: We demonstrated a novel theranostic system for simultaneous photothermal therapy and magnetic resonance imaging applicable to early diagnostics and treatment of cancer cells. Materials & methods: Oleic acid-Fe3O4 and triphenylamine-divinylanthracene-dicyano were loaded to the poly(L-lactic-co-glycolic acid) nanoparticles (NPs) on which anti-VEGF antibodies were modified to form anti-VEGF/OA-Fe3O4/triphenylamine-divinylanthracene-dicyano@poly(L-lactic-co-glycolic acid) NPs. The 1H nuclear magnetic resonance (NMR), mass spectra, fluorescence, UV absorption, dynamic light scattering, transmission electron microscope and inductively coupled plasma mass spectrometry tests were used to characterize the NPs, and the bioimaging was illustrated by confocal laser scanning microscope (CLSM) and in vivo MRI animal experiment. Results: This system was capable to recognize the overexpressed VEGF-A as low as 68 pg/ml in different cell lines with good selectivity and photothermal therapy effect. Conclusion: These ultrasensitive theranostic NPs were able to identify tumor cells by fluorescence imaging and MRI, and destroy tumors under near infrared illumination.

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http://hdl.handle.net/10453/140424