Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages.

Viljoen, A; Raynaud, C; Johansen, MD; Roquet-Banères, F; Herrmann, J-L; Daher, W; Kremer, L

Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages.

Viljoen, A Raynaud, C Johansen, MD Roquet-Banères, F Herrmann, J-L Daher, W Kremer, L

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Publisher:: American Society for Microbiology
Publication Type:: Journal Article
Citation:: Antimicrobial agents and chemotherapy, 2019, 63, (9)
Issue Date:: 2019-09

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Field	Value	Language
dc.contributor.author	Viljoen, A
dc.contributor.author	Raynaud, C
dc.contributor.author	Johansen, MD
dc.contributor.author	Roquet-Banères, F
dc.contributor.author	Herrmann, J-L
dc.contributor.author	Daher, W
dc.contributor.author	Kremer, L
dc.date.accessioned	2020-05-20T23:50:07Z
dc.date.available	2019-06-10
dc.date.available	2020-05-20T23:50:07Z
dc.date.issued	2019-09
dc.identifier.citation	Antimicrobial agents and chemotherapy, 2019, 63, (9)
dc.identifier.issn	0066-4804
dc.identifier.issn	1098-6596
dc.identifier.uri	http://hdl.handle.net/10453/140857
dc.description.abstract	Due to intrinsic multidrug resistance, pulmonary infections with Mycobacterium abscessus are extremely difficult to treat. Previously, we demonstrated that bedaquiline is highly effective against Mycobacterium abscessus both in vitro and in vivo Here, we report that verapamil improves the efficacy of bedaquiline activity against M. abscessus clinical isolates and low-level resistant strains, both in vitro and in macrophages. Verapamil may have clinical potential as adjunctive therapy provided that sufficiently high doses can be safely achieved.
dc.format	Electronic-Print
dc.language	eng
dc.publisher	American Society for Microbiology
dc.relation.ispartof	Antimicrobial agents and chemotherapy
dc.relation.isbasedon	10.1128/aac.00705-19
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	0605 Microbiology, 1108 Medical Microbiology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Microbiology
dc.title	Verapamil Improves the Activity of Bedaquiline against Mycobacterium abscessus In Vitro and in Macrophages.
dc.type	Journal Article
utslib.citation.volume	63
utslib.location.activity	United States
utslib.for	0605 Microbiology
utslib.for	1108 Medical Microbiology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	0605 Microbiology
utslib.for	1108 Medical Microbiology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2020-05-20T23:50:01Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	63
utslib.citation.issue	9

Abstract:

Due to intrinsic multidrug resistance, pulmonary infections with Mycobacterium abscessus are extremely difficult to treat. Previously, we demonstrated that bedaquiline is highly effective against Mycobacterium abscessus both in vitro and in vivo Here, we report that verapamil improves the efficacy of bedaquiline activity against M. abscessus clinical isolates and low-level resistant strains, both in vitro and in macrophages. Verapamil may have clinical potential as adjunctive therapy provided that sufficiently high doses can be safely achieved.

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http://hdl.handle.net/10453/140857