Gene expression and the development of live enteric vaccines.

Charles, I; Dougan, G

Gene expression and the development of live enteric vaccines.

Charles, I Dougan, G

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Publication Type:: Journal Article
Citation:: Trends Biotechnol, 1990, 8 (5), pp. 117 - 121
Issue Date:: 1990-05

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Field	Value	Language
dc.contributor.author	Charles, I	en_US
dc.contributor.author	Dougan, G	en_US
dc.date.issued	1990-05	en_US
dc.identifier.citation	Trends Biotechnol, 1990, 8 (5), pp. 117 - 121	en_US
dc.identifier.issn	0167-7799	en_US
dc.identifier.uri	http://hdl.handle.net/10453/14177
dc.description.abstract	Rationally attenuated live Salmonella vaccines provide good protection against homologous challenge and can act as carriers of heterologous antigens. However, the optimum expression system for each heterologous antigen will need to be established individually. This will ensure that the antigen in question is produced at appropriate levels, in the correctly folded conformation, within or at the surface of the carrier cell, and can therefore elicit the optimal immune response.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Trends Biotechnol	en_US
dc.relation.isbasedon	10.1016/0167-7799(90)90151-m	en_US
dc.subject.classification	Biotechnology	en_US
dc.subject.mesh	Intestines	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Vaccines, Synthetic	en_US
dc.subject.mesh	Vaccines	en_US
dc.subject.mesh	Vaccines, Attenuated	en_US
dc.subject.mesh	Antigens, Bacterial	en_US
dc.subject.mesh	Gene Expression	en_US
dc.title	Gene expression and the development of live enteric vaccines.	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	8	en_US
utslib.location.activity	England	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	10 Technology	en_US
dc.location.activity	Las Vegas, NV
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	8	en_US

Abstract:

Rationally attenuated live Salmonella vaccines provide good protection against homologous challenge and can act as carriers of heterologous antigens. However, the optimum expression system for each heterologous antigen will need to be established individually. This will ensure that the antigen in question is produced at appropriate levels, in the correctly folded conformation, within or at the surface of the carrier cell, and can therefore elicit the optimal immune response.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/14177