Inducible Nitric Oxide Synthase Polymorphism And Fatal Cerebral Malaria

Lancet Ltd
Publication Type:
Journal Article
The Lancet, 1998, 352 (9135), pp. 1193 - 1194
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There has been much speculation about the part played by nitric oxide (NO) in malaria, both as an antiparasitic agent and as a potential cause of neurosuppression leading to cerebral malaria.[1] and [2] Investigation is hampered by difficulty in estimating in-vivo production of NO, but genetic studies provide a potential means of examining the relation between NO production and disease outcome. A report from Gabon suggests that a single nucleotide polymorphism in the inducible nitric oxide synthase (NOS2) promoter is associated with protection from all forms of severe malaria, including susceptibility to reinfection.3 We present data from The Gambia suggesting that a similar region of the NOS2 gene encodes a susceptibility determinant for fatal cerebral malaria.
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