Dopamine: an immune transmitter.

Thomas Broome, S; Louangaphay, K; Keay, KA; Leggio, GM; Musumeci, G; Castorina, A

Dopamine: an immune transmitter.

Thomas Broome, S Louangaphay, K Keay, KA Leggio, GM Musumeci, G Castorina, A

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Publisher:: WOLTERS KLUWER MEDKNOW PUBLICATIONS
Publication Type:: Journal Article
Citation:: Neural regeneration research, 2020, 15, (12), pp. 2173-2185
Issue Date:: 2020-12

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Field	Value	Language
dc.contributor.author	Thomas Broome, S
dc.contributor.author	Louangaphay, K
dc.contributor.author	Keay, KA
dc.contributor.author	Leggio, GM
dc.contributor.author	Musumeci, G
dc.contributor.author	Castorina, A https://orcid.org/0000-0001-7037-759X
dc.date.accessioned	2020-07-21T07:28:38Z
dc.date.available	2020-07-21T07:28:38Z
dc.date.issued	2020-12
dc.identifier.citation	Neural regeneration research, 2020, 15, (12), pp. 2173-2185
dc.identifier.issn	1673-5374
dc.identifier.issn	1876-7958
dc.identifier.uri	http://hdl.handle.net/10453/141826
dc.description.abstract	The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson's disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson's disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies.
dc.format	Print
dc.language	eng
dc.publisher	WOLTERS KLUWER MEDKNOW PUBLICATIONS
dc.relation.ispartof	Neural regeneration research
dc.relation.isbasedon	10.4103/1673-5374.284976
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1109 Neurosciences
dc.title	Dopamine: an immune transmitter.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	India
utslib.for	1109 Neurosciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
dc.date.updated	2020-07-21T07:28:33Z
pubs.issue	12
pubs.publication-status	Accepted
pubs.volume	15
utslib.citation.issue	12

Abstract:

The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson's disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson's disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies.

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http://hdl.handle.net/10453/141826