Research into Neospora caninum-What Have We Learnt in the Last Thirty Years?

Reichel, MP; Wahl, LC; Ellis, JT

Research into Neospora caninum-What Have We Learnt in the Last Thirty Years?

Reichel, MP Wahl, LC Ellis, JT

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Pathogens (Basel, Switzerland), 2020, 9, (6)
Issue Date:: 2020-06-23

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Field	Value	Language
dc.contributor.author	Reichel, MP
dc.contributor.author	Wahl, LC
dc.contributor.author	Ellis, JT
dc.date.accessioned	2020-09-10T03:03:58Z
dc.date.available	2020-06-21
dc.date.available	2020-09-10T03:03:58Z
dc.date.issued	2020-06-23
dc.identifier.citation	Pathogens (Basel, Switzerland), 2020, 9, (6)
dc.identifier.issn	2076-0817
dc.identifier.issn	2076-0817
dc.identifier.uri	http://hdl.handle.net/10453/142604
dc.description.abstract	BACKGROUND:Neospora caninum has been recognised world-wide, first as a disease of dogs, then as an important cause of abortions in cattle for the past thirty years. Over that time period, there have been improvements in the diagnosis of infection and abortion, new tests have been developed and validated, and it is timely to review progress to date. METHODS:Bibliometric methods were used to identify major trends and research topics present in the published literature on N. caninum. The tools used were SWIFT-Review, VOSviewer and SciMAT, along with the published papers found in the MEDLINE, Dimensions and Web of Science databases. A systematic review of the published Neospora literature (n = 2933) was also carried out via MEDLINE and systematically appraised for publications relevant to the pathogenesis, pathology and diagnosis of Neospora abortions. RESULTS:A total of 92 publications were included in the final analysis and grouped into four main time periods. In these four different time periods, the main research themes were "dogs", "abortion", "seroprevalence" and "infection". Diagnostics, including PCR, dominated the first two time periods, with an increased focus on transmission and abortions, and its risk factors in cattle. CONCLUSIONS:Longitudinal analyses indicated that the main themes were consistently investigated over the last 30 years through a wide range of studies, with evolving emphasis initially on dogs and diagnostic test development, followed by application to cattle, the identification of the risk factors leading to abortion, and in the latter time periods, an understanding of the immunity and a search for vaccines.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Pathogens (Basel, Switzerland)
dc.relation.isbasedon	10.3390/pathogens9060505
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1107 Immunology, 1108 Medical Microbiology
dc.title	Research into Neospora caninum-What Have We Learnt in the Last Thirty Years?
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	Switzerland
utslib.for	1107 Immunology
utslib.for	1108 Medical Microbiology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
dc.date.updated	2020-09-10T03:03:33Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	9
utslib.citation.issue	6

Abstract:

BACKGROUND:Neospora caninum has been recognised world-wide, first as a disease of dogs, then as an important cause of abortions in cattle for the past thirty years. Over that time period, there have been improvements in the diagnosis of infection and abortion, new tests have been developed and validated, and it is timely to review progress to date. METHODS:Bibliometric methods were used to identify major trends and research topics present in the published literature on N. caninum. The tools used were SWIFT-Review, VOSviewer and SciMAT, along with the published papers found in the MEDLINE, Dimensions and Web of Science databases. A systematic review of the published Neospora literature (n = 2933) was also carried out via MEDLINE and systematically appraised for publications relevant to the pathogenesis, pathology and diagnosis of Neospora abortions. RESULTS:A total of 92 publications were included in the final analysis and grouped into four main time periods. In these four different time periods, the main research themes were "dogs", "abortion", "seroprevalence" and "infection". Diagnostics, including PCR, dominated the first two time periods, with an increased focus on transmission and abortions, and its risk factors in cattle. CONCLUSIONS:Longitudinal analyses indicated that the main themes were consistently investigated over the last 30 years through a wide range of studies, with evolving emphasis initially on dogs and diagnostic test development, followed by application to cattle, the identification of the risk factors leading to abortion, and in the latter time periods, an understanding of the immunity and a search for vaccines.

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http://hdl.handle.net/10453/142604