Acute neuromodulation restores spinally-induced motor responses after severe spinal cord injury.

Taccola, G; Gad, P; Culaclii, S; Wang, P-M; Liu, W; Edgerton, VR

Acute neuromodulation restores spinally-induced motor responses after severe spinal cord injury.

Taccola, G Gad, P Culaclii, S Wang, P-M Liu, W Edgerton, VR

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Experimental neurology, 2020, 327
Issue Date:: 2020-05

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Field	Value	Language
dc.contributor.author	Taccola, G
dc.contributor.author	Gad, P
dc.contributor.author	Culaclii, S
dc.contributor.author	Wang, P-M
dc.contributor.author	Liu, W
dc.contributor.author	Edgerton, VR
dc.date.accessioned	2020-10-22T03:51:30Z
dc.date.available	2020-02-10
dc.date.available	2020-10-22T03:51:30Z
dc.date.issued	2020-05
dc.identifier.citation	Experimental neurology, 2020, 327
dc.identifier.issn	0014-4886
dc.identifier.issn	1090-2430
dc.identifier.uri	http://hdl.handle.net/10453/143466
dc.description.abstract	Epidural electrical spinal stimulation can facilitate recovery of volitional motor control in individuals that have been completely paralyzed for more than a year. We recently reported a novel neuromodulation method named Dynamic Stimulation (DS), which short-lastingly increased spinal excitability and generated a robust modulation of locomotor networks in fully-anesthetized intact adult rats. In the present study, we applied repetitive DS patterns to four lumbosacral segments acutely after a contusive injury at lumbar level. Repetitive DS delivery restored the spinally-evoked motor EMG responses that were previously suppressed by a calibrated spinal cord contusion. Sham experiments without DS delivery did not allow any spontaneous recovery. Thus, DS uniquely provides the potential for a greater long-term functional recovery after paralysis.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Experimental neurology
dc.relation.isbasedon	10.1016/j.expneurol.2020.113246
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1103 Clinical Sciences, 1109 Neurosciences, 1701 Psychology
dc.subject.classification	Neurology & Neurosurgery
dc.title	Acute neuromodulation restores spinally-induced motor responses after severe spinal cord injury.
dc.type	Journal Article
utslib.citation.volume	327
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
utslib.for	1701 Psychology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-10-22T03:51:05Z
pubs.publication-status	Published
pubs.volume	327

Abstract:

Epidural electrical spinal stimulation can facilitate recovery of volitional motor control in individuals that have been completely paralyzed for more than a year. We recently reported a novel neuromodulation method named Dynamic Stimulation (DS), which short-lastingly increased spinal excitability and generated a robust modulation of locomotor networks in fully-anesthetized intact adult rats. In the present study, we applied repetitive DS patterns to four lumbosacral segments acutely after a contusive injury at lumbar level. Repetitive DS delivery restored the spinally-evoked motor EMG responses that were previously suppressed by a calibrated spinal cord contusion. Sham experiments without DS delivery did not allow any spontaneous recovery. Thus, DS uniquely provides the potential for a greater long-term functional recovery after paralysis.

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http://hdl.handle.net/10453/143466