Animal and translational models of SARS-CoV-2 infection and COVID-19.

Johansen, MD; Irving, A; Montagutelli, X; Tate, MD; Rudloff, I; Nold, MF; Hansbro, NG; Kim, RY; Donovan, C; Liu, G; Faiz, A; Short, KR; Lyons, JG; McCaughan, GW; Gorrell, MD; Cole, A; Moreno, C; Couteur, D; Hesselson, D; Triccas, J; Neely, GG; Gamble, JR; Simpson, SJ; Saunders, BM; Oliver, BG; Britton, WJ; Wark, PA; Nold-Petry, CA; Hansbro, PM

Animal and translational models of SARS-CoV-2 infection and COVID-19.

Johansen, MD Irving, A Montagutelli, X Tate, MD Rudloff, I Nold, MF Hansbro, NG Kim, RY Donovan, C

Liu, G

Faiz, A

Short, KR Lyons, JG McCaughan, GW Gorrell, MD Cole, A Moreno, C Couteur, D Hesselson, D Triccas, J Neely, GG Gamble, JR Simpson, SJ Saunders, BM Oliver, BG Britton, WJ Wark, PA Nold-Petry, CA Hansbro, PM

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Publisher:: SPRINGERNATURE
Publication Type:: Journal Article
Citation:: Mucosal immunology, 2020, 13, (6), pp. 877-891
Issue Date:: 2020-08-20

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Field	Value	Language
dc.contributor.author	Johansen, MD
dc.contributor.author	Irving, A
dc.contributor.author	Montagutelli, X
dc.contributor.author	Tate, MD
dc.contributor.author	Rudloff, I
dc.contributor.author	Nold, MF
dc.contributor.author	Hansbro, NG
dc.contributor.author	Kim, RY
dc.contributor.author	Donovan, C https://orcid.org/0000-0003-4558-329X
dc.contributor.author	Liu, G https://orcid.org/0000-0002-0489-2638
dc.contributor.author	Faiz, A https://orcid.org/0000-0003-1740-3538
dc.contributor.author	Short, KR
dc.contributor.author	Lyons, JG
dc.contributor.author	McCaughan, GW
dc.contributor.author	Gorrell, MD
dc.contributor.author	Cole, A
dc.contributor.author	Moreno, C
dc.contributor.author	Couteur, D
dc.contributor.author	Hesselson, D
dc.contributor.author	Triccas, J
dc.contributor.author	Neely, GG
dc.contributor.author	Gamble, JR
dc.contributor.author	Simpson, SJ
dc.contributor.author	Saunders, BM
dc.contributor.author	Oliver, BG
dc.contributor.author	Britton, WJ
dc.contributor.author	Wark, PA
dc.contributor.author	Nold-Petry, CA
dc.contributor.author	Hansbro, PM
dc.date.accessioned	2020-10-22T04:48:09Z
dc.date.available	2020-07-31
dc.date.available	2020-10-22T04:48:09Z
dc.date.issued	2020-08-20
dc.identifier.citation	Mucosal immunology, 2020, 13, (6), pp. 877-891
dc.identifier.issn	1933-0219
dc.identifier.issn	1935-3456
dc.identifier.uri	http://hdl.handle.net/10453/143469
dc.description.abstract	COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SPRINGERNATURE
dc.relation	Maridulu Budyari Gumal - The Sydney Partnership for Health, Education, Research and Enterprise (SPHERE)RSEOH CAG SPHERE
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation.ispartof	Mucosal immunology
dc.relation.isbasedon	10.1038/s41385-020-00340-z
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences
dc.subject.classification	Immunology
dc.title	Animal and translational models of SARS-CoV-2 infection and COVID-19.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	United States
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-10-22T04:47:40Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	13
utslib.citation.issue	6

Abstract:

COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/143469