Biodegradable Nanoprodrugs: “Delivering” ROS to Cancer Cells for Molecular Dynamic Therapy

Tang, ZM; Liu, YY; Ni, DL; Zhou, JJ; Zhang, M; Zhao, PR; Lv, B; Wang, H; Jin, DY; Bu, WB

Biodegradable Nanoprodrugs: “Delivering” ROS to Cancer Cells for Molecular Dynamic Therapy

Tang, ZM Liu, YY Ni, DL Zhou, JJ Zhang, M Zhao, PR Lv, B Wang, H Jin, DY Bu, WB

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Advanced Materials, 2020, 32, (4)
Issue Date:: 2020

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Field	Value	Language
dc.contributor.author	Tang, ZM
dc.contributor.author	Liu, YY
dc.contributor.author	Ni, DL
dc.contributor.author	Zhou, JJ
dc.contributor.author	Zhang, M
dc.contributor.author	Zhao, PR
dc.contributor.author	Lv, B
dc.contributor.author	Wang, H
dc.contributor.author	Jin, DY
dc.contributor.author	Bu, WB
dc.date.accessioned	2020-10-23T04:52:44Z
dc.date.available	2020-10-23T04:52:44Z
dc.date.issued	2020
dc.identifier.citation	Advanced Materials, 2020, 32, (4)
dc.identifier.issn	0935-9648
dc.identifier.issn	1521-4095
dc.identifier.uri	http://hdl.handle.net/10453/143507
dc.description.abstract	© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next-generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin-modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg2+. This reaction simultaneously produces abundant H2O2 to induce cell death and damage the structure of transferrin to release Fe3+, which will react with H2O2 to produce highly toxic ·OH to kill tumor cells.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Advanced Materials
dc.relation.isbasedon	10.1002/adma.201904011
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	02 Physical Sciences, 03 Chemical Sciences, 09 Engineering
dc.subject.classification	Nanoscience & Nanotechnology
dc.title	Biodegradable Nanoprodrugs: “Delivering” ROS to Cancer Cells for Molecular Dynamic Therapy
dc.type	Journal Article
utslib.citation.volume	32
utslib.location.activity	Germany
utslib.for	02 Physical Sciences
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2020-10-23T04:52:07Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	32
utslib.citation.issue	4

Abstract:

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next-generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin-modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg2+. This reaction simultaneously produces abundant H2O2 to induce cell death and damage the structure of transferrin to release Fe3+, which will react with H2O2 to produce highly toxic ·OH to kill tumor cells.

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http://hdl.handle.net/10453/143507