Comparative analysis of NF KB in the MyD88 mediated pathway after implantation of titanium alloy and stainless steel and the role of regulatory T cells.
- Publisher:
- Elsevier BV
- Publication Type:
- Journal Article
- Citation:
- World neurosurgery, 2020
- Issue Date:
- 2020-08-08
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1-s2.0-S1878875020317800-main.pdf | Published version | 2.34 MB |
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OBJECTIVE: Development of immunologically smart implants, integrated to biological systems, is a key aim to minimize the inflammatory response of the host to biomaterial implants. METHODS: The aim of this study is to investigate the influence of titanium alloy and stainless steel implants on immunological responses in rats by comparative analysis of nuclear factor kappa B (NF-κB) profiles in the activation of inflammatory signaling pathways and the role of CD4+CD25+Foxp3+. RESULTS: Both Ti alloy and stainless steel alloy group implantation affect Toll-like receptors-4 pathways and CD4+CD25+ regulatory T cells in different ways. CONCLUSIONS: Results show that NF-κB/p65 and NF-κB1/p50 possess potential as a therapeutic target in the prevention of adverse reactions to metal, especially for controlling inflammation after the implantation.
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