Comparative analysis of NF KB in the MyD88 mediated pathway after implantation of titanium alloy and stainless steel and the role of regulatory T cells.

Akyol, S; Yetmez, M; Akgun, MY; Hanci, M; Oktar, FN; Ben-Nissan, B

Comparative analysis of NF KB in the MyD88 mediated pathway after implantation of titanium alloy and stainless steel and the role of regulatory T cells.

Akyol, S Yetmez, M Akgun, MY Hanci, M Oktar, FN Ben-Nissan, B

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: World neurosurgery, 2020
Issue Date:: 2020-08-08

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Field	Value	Language
dc.contributor.author	Akyol, S
dc.contributor.author	Yetmez, M
dc.contributor.author	Akgun, MY
dc.contributor.author	Hanci, M
dc.contributor.author	Oktar, FN
dc.contributor.author	Ben-Nissan, B
dc.date.accessioned	2020-11-13T19:40:00Z
dc.date.available	2020-08-03
dc.date.available	2020-11-13T19:40:00Z
dc.date.issued	2020-08-08
dc.identifier.citation	World neurosurgery, 2020
dc.identifier.issn	1878-8750
dc.identifier.issn	1878-8769
dc.identifier.uri	http://hdl.handle.net/10453/143980
dc.description.abstract	OBJECTIVE: Development of immunologically smart implants, integrated to biological systems, is a key aim to minimize the inflammatory response of the host to biomaterial implants. METHODS: The aim of this study is to investigate the influence of titanium alloy and stainless steel implants on immunological responses in rats by comparative analysis of nuclear factor kappa B (NF-κB) profiles in the activation of inflammatory signaling pathways and the role of CD4+CD25+Foxp3+. RESULTS: Both Ti alloy and stainless steel alloy group implantation affect Toll-like receptors-4 pathways and CD4+CD25+ regulatory T cells in different ways. CONCLUSIONS: Results show that NF-κB/p65 and NF-κB1/p50 possess potential as a therapeutic target in the prevention of adverse reactions to metal, especially for controlling inflammation after the implantation.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	World neurosurgery
dc.relation.isbasedon	10.1016/j.wneu.2020.08.016
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1103 Clinical Sciences, 1109 Neurosciences
dc.title	Comparative analysis of NF KB in the MyD88 mediated pathway after implantation of titanium alloy and stainless steel and the role of regulatory T cells.
dc.type	Journal Article
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2020-11-13T19:39:56Z
pubs.publication-status	Published

Abstract:

OBJECTIVE: Development of immunologically smart implants, integrated to biological systems, is a key aim to minimize the inflammatory response of the host to biomaterial implants. METHODS: The aim of this study is to investigate the influence of titanium alloy and stainless steel implants on immunological responses in rats by comparative analysis of nuclear factor kappa B (NF-κB) profiles in the activation of inflammatory signaling pathways and the role of CD4+CD25+Foxp3+. RESULTS: Both Ti alloy and stainless steel alloy group implantation affect Toll-like receptors-4 pathways and CD4+CD25+ regulatory T cells in different ways. CONCLUSIONS: Results show that NF-κB/p65 and NF-κB1/p50 possess potential as a therapeutic target in the prevention of adverse reactions to metal, especially for controlling inflammation after the implantation.

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http://hdl.handle.net/10453/143980