Characterization of Upconversion Nanoparticles by Single-Particle ICP-MS Employing a Quadrupole Mass Filter with Increased Bandpass.

Meyer, S; Gonzalez de Vega, R; Xu, X; Du, Z; Doble, PA; Clases, D

Characterization of Upconversion Nanoparticles by Single-Particle ICP-MS Employing a Quadrupole Mass Filter with Increased Bandpass.

Meyer, S Gonzalez de Vega, R

Xu, X

Du, Z Doble, PA Clases, D

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Publisher:: American Chemical Society (ACS)
Publication Type:: Journal Article
Citation:: Analytical chemistry, 2020, 92, pp. 15007-15016
Issue Date:: 2020-11-02

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Field	Value	Language
dc.contributor.author	Meyer, S
dc.contributor.author	Gonzalez de Vega, R https://orcid.org/0000-0002-9806-9633
dc.contributor.author	Xu, X https://orcid.org/0000-0002-2598-3766
dc.contributor.author	Du, Z
dc.contributor.author	Doble, PA
dc.contributor.author	Clases, D https://orcid.org/0000-0003-3880-9385
dc.date.accessioned	2020-11-18T05:24:46Z
dc.date.available	2020-11-18T05:24:46Z
dc.date.issued	2020-11-02
dc.identifier.citation	Analytical chemistry, 2020, 92, pp. 15007-15016
dc.identifier.issn	0003-2700
dc.identifier.issn	1520-6882
dc.identifier.uri	http://hdl.handle.net/10453/144121
dc.description.abstract	This work introduces new methods to characterize dispersions of small-diameter or low-mass-fraction nanoparticles (NPs) by single-particle inductively coupled plasma-mass spectrometry (SP ICP-MS). The optimization of ion extraction, ion transport, and the operation of the quadrupole with increased mass bandwidth improved the signal-to-noise ratios significantly and decreased the size detection limits for all NP dispersions investigated. As a model system, 10.9 ± 1.0 nm Au NPs were analyzed to demonstrate the effects of increasing ion transmission. Specifically, increasing the mass bandwidth of the quadrupole improved the size detection limit to 4.2 nm and enabled the resolution of NP signals from ionic background and noise. Subsequently, the methods were applied to the characterization of lanthanide-doped upconversion nanoparticles (UCNPs) by SP ICP-MS. Three different types of UCNPs (90 nm NaYF4: 20% Yb, 2% Er; 20 nm NaGdF4: 20% Yb, 1% Er; 15 nm NaYF4: 20% Yb, 2% Er) were investigated. Y showed the best signal-to-noise ratios with optimized ion extraction and transport parameters only, whereas the signal-to-noise ratios of Gd, Er, and Yb were further improved by increasing the mass bandwidth of a quadrupole mass filter. The novel methods were suitable for detailed characterization of diluted UCNP dispersions including particle stoichiometries and size distributions. A Poisson model was further applied to assess particle-particle interactions in the aqueous dispersions. The methods have considerable potential for the characterization of small-diameter and/or low-mass-fraction nanoparticles.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American Chemical Society (ACS)
dc.relation	http://purl.org/au-research/grants/arc/DP190102361
dc.relation	German Research Foundation417283954
dc.relation.ispartof	Analytical chemistry
dc.relation.isbasedon	10.1021/acs.analchem.0c02925
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Analytical Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see http://doi.org/10.1021/acs.analchem.0c02925
dc.subject	0301 Analytical Chemistry, 0399 Other Chemical Sciences
dc.subject.classification	Analytical Chemistry
dc.title	Characterization of Upconversion Nanoparticles by Single-Particle ICP-MS Employing a Quadrupole Mass Filter with Increased Bandpass.
dc.type	Journal Article
utslib.citation.volume	92
utslib.location.activity	United States
utslib.for	0301 Analytical Chemistry
utslib.for	0399 Other Chemical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2020-11-18T05:24:42Z
pubs.publication-status	Published
pubs.volume	92

Abstract:

This work introduces new methods to characterize dispersions of small-diameter or low-mass-fraction nanoparticles (NPs) by single-particle inductively coupled plasma-mass spectrometry (SP ICP-MS). The optimization of ion extraction, ion transport, and the operation of the quadrupole with increased mass bandwidth improved the signal-to-noise ratios significantly and decreased the size detection limits for all NP dispersions investigated. As a model system, 10.9 ± 1.0 nm Au NPs were analyzed to demonstrate the effects of increasing ion transmission. Specifically, increasing the mass bandwidth of the quadrupole improved the size detection limit to 4.2 nm and enabled the resolution of NP signals from ionic background and noise. Subsequently, the methods were applied to the characterization of lanthanide-doped upconversion nanoparticles (UCNPs) by SP ICP-MS. Three different types of UCNPs (90 nm NaYF4: 20% Yb, 2% Er; 20 nm NaGdF4: 20% Yb, 1% Er; 15 nm NaYF4: 20% Yb, 2% Er) were investigated. Y showed the best signal-to-noise ratios with optimized ion extraction and transport parameters only, whereas the signal-to-noise ratios of Gd, Er, and Yb were further improved by increasing the mass bandwidth of a quadrupole mass filter. The novel methods were suitable for detailed characterization of diluted UCNP dispersions including particle stoichiometries and size distributions. A Poisson model was further applied to assess particle-particle interactions in the aqueous dispersions. The methods have considerable potential for the characterization of small-diameter and/or low-mass-fraction nanoparticles.

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http://hdl.handle.net/10453/144121