The association of pretransplant dialysis exposure with transplant failure is dependent on the state-specific rate of dialysis mortality.

Gill, JS; Clark, S; Kadatz, M; Gill, J

The association of pretransplant dialysis exposure with transplant failure is dependent on the state-specific rate of dialysis mortality.

Gill, JS Clark, S

Kadatz, M Gill, J

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020, 20, (9), pp. 2481-2490
Issue Date:: 2020-09

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Field	Value	Language
dc.contributor.author	Gill, JS
dc.contributor.author	Clark, S https://orcid.org/0000-0002-1452-9912
dc.contributor.author	Kadatz, M
dc.contributor.author	Gill, J
dc.date.accessioned	2020-11-23T05:41:52Z
dc.date.available	2020-04-02
dc.date.available	2020-11-23T05:41:52Z
dc.date.issued	2020-09
dc.identifier.citation	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020, 20, (9), pp. 2481-2490
dc.identifier.issn	1600-6143
dc.identifier.issn	1600-6143
dc.identifier.uri	http://hdl.handle.net/10453/144258
dc.description.abstract	Longer pretransplant dialysis exposure is associated with a higher risk of transplant failure. Whether patients who receive dialysis in a region with a higher rate of dialysis mortality are a higher risk for transplant failure is unknown. Adjusted state-specific hemodialysis mortality rates were determined in 3-year intervals among prevalent dialysis patients in the United States between 1995 and 2012. The effect of state- and period-specific dialysis mortality on the association of pretransplant dialysis exposure with transplant survival through December 2017 was determined using multivariable models. Dialysis mortality within states ranged from 128 deaths/1000 patient-years to 330 deaths/1000 patient-years. Each additional year of dialysis was associated with a 4% higher risk of transplant failure in states within the lowest quartile of dialysis mortality, compared with an 8% higher risk in states within the highest quartile of dialysis mortality. Patients who received pretransplant dialysis treatment in a state with a high rate of dialysis mortality are at a higher risk for transplant failure compared with patients with the same duration of pretransplant dialysis treatment in a state with a lower mortality rate. The findings may have implications for dialysis care in transplant candidates and the design of future outcome metrics.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
dc.relation.isbasedon	10.1111/ajt.15917
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	Surgery
dc.title	The association of pretransplant dialysis exposure with transplant failure is dependent on the state-specific rate of dialysis mortality.
dc.type	Journal Article
utslib.citation.volume	20
utslib.location.activity	United States
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-11-23T05:41:48Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	20
utslib.citation.issue	9

Abstract:

Longer pretransplant dialysis exposure is associated with a higher risk of transplant failure. Whether patients who receive dialysis in a region with a higher rate of dialysis mortality are a higher risk for transplant failure is unknown. Adjusted state-specific hemodialysis mortality rates were determined in 3-year intervals among prevalent dialysis patients in the United States between 1995 and 2012. The effect of state- and period-specific dialysis mortality on the association of pretransplant dialysis exposure with transplant survival through December 2017 was determined using multivariable models. Dialysis mortality within states ranged from 128 deaths/1000 patient-years to 330 deaths/1000 patient-years. Each additional year of dialysis was associated with a 4% higher risk of transplant failure in states within the lowest quartile of dialysis mortality, compared with an 8% higher risk in states within the highest quartile of dialysis mortality. Patients who received pretransplant dialysis treatment in a state with a high rate of dialysis mortality are at a higher risk for transplant failure compared with patients with the same duration of pretransplant dialysis treatment in a state with a lower mortality rate. The findings may have implications for dialysis care in transplant candidates and the design of future outcome metrics.

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http://hdl.handle.net/10453/144258