ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.

Ubags, ND; Baker, J; Boots, A; Costa, R; El-Merhie, N; Fabre, A; Faiz, A; Heijink, IH; Hiemstra, PS; Lehmann, M; Meiners, S; Rolandsson Enes, S; Bartel, S

ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.

Ubags, ND Baker, J Boots, A Costa, R El-Merhie, N Fabre, A Faiz, A

Heijink, IH Hiemstra, PS Lehmann, M Meiners, S Rolandsson Enes, S Bartel, S

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Publisher:: European Respiratory Society (ERS)
Publication Type:: Journal Article
Citation:: ERJ open research, 2020, 6, (1), pp. 00350-2019
Issue Date:: 2020-01

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Field	Value	Language
dc.contributor.author	Ubags, ND
dc.contributor.author	Baker, J
dc.contributor.author	Boots, A
dc.contributor.author	Costa, R
dc.contributor.author	El-Merhie, N
dc.contributor.author	Fabre, A
dc.contributor.author	Faiz, A https://orcid.org/0000-0003-1740-3538
dc.contributor.author	Heijink, IH
dc.contributor.author	Hiemstra, PS
dc.contributor.author	Lehmann, M
dc.contributor.author	Meiners, S
dc.contributor.author	Rolandsson Enes, S
dc.contributor.author	Bartel, S
dc.date.accessioned	2020-11-25T05:50:28Z
dc.date.available	2020-01-26
dc.date.available	2020-11-25T05:50:28Z
dc.date.issued	2020-01
dc.identifier.citation	ERJ open research, 2020, 6, (1), pp. 00350-2019
dc.identifier.issn	2312-0541
dc.identifier.issn	2312-0541
dc.identifier.uri	http://hdl.handle.net/10453/144343
dc.description.abstract	In this review, the Basic and Translational Sciences Assembly of the European Respiratory Society (ERS) provides an overview of the 2019 ERS International Congress highlights. In particular, we discuss how the novel and very promising technology of single cell sequencing has led to the development of a comprehensive map of the human lung, the lung cell atlas, including the discovery of novel cell types and new insights into cellular trajectories in lung health and disease. Further, we summarise recent insights in the field of respiratory infections, which can aid in a better understanding of the molecular mechanisms underlying these infections in order to develop novel vaccines and improved treatment options. Novel concepts delineating the early origins of lung disease are focused on the effects of pre- and post-natal exposures on neonatal lung development and long-term lung health. Moreover, we discuss how these early life exposures can affect the lung microbiome and respiratory infections. In addition, the importance of metabolomics and mitochondrial function analysis to subphenotype chronic lung disease patients according to their metabolic program is described. Finally, basic and translational respiratory science is rapidly moving forward and this will be beneficial for an advanced molecular understanding of the mechanisms underlying a variety of lung diseases. In the long-term this will aid in the development of novel therapeutic targeting strategies in the field of respiratory medicine.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	European Respiratory Society (ERS)
dc.relation.ispartof	ERJ open research
dc.relation.isbasedon	10.1183/23120541.00350-2019
dc.rights	info:eu-repo/semantics/openAccess
dc.title	ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.
dc.type	Journal Article
utslib.citation.volume	6
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2020-11-25T05:50:20Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	6
utslib.citation.issue	1

Abstract:

In this review, the Basic and Translational Sciences Assembly of the European Respiratory Society (ERS) provides an overview of the 2019 ERS International Congress highlights. In particular, we discuss how the novel and very promising technology of single cell sequencing has led to the development of a comprehensive map of the human lung, the lung cell atlas, including the discovery of novel cell types and new insights into cellular trajectories in lung health and disease. Further, we summarise recent insights in the field of respiratory infections, which can aid in a better understanding of the molecular mechanisms underlying these infections in order to develop novel vaccines and improved treatment options. Novel concepts delineating the early origins of lung disease are focused on the effects of pre- and post-natal exposures on neonatal lung development and long-term lung health. Moreover, we discuss how these early life exposures can affect the lung microbiome and respiratory infections. In addition, the importance of metabolomics and mitochondrial function analysis to subphenotype chronic lung disease patients according to their metabolic program is described. Finally, basic and translational respiratory science is rapidly moving forward and this will be beneficial for an advanced molecular understanding of the mechanisms underlying a variety of lung diseases. In the long-term this will aid in the development of novel therapeutic targeting strategies in the field of respiratory medicine.

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http://hdl.handle.net/10453/144343