Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders.

Alemao, CA; Budden, KF; Gomez, HM; Rehman, SF; Marshall, JE; Shukla, SD; Donovan, C; Forster, SC; Yang, IA; Keely, S; Mann, ER; El Omar, EM; Belz, GT; Hansbro, PM

Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders.

Alemao, CA Budden, KF Gomez, HM Rehman, SF Marshall, JE Shukla, SD Donovan, C

Forster, SC Yang, IA Keely, S Mann, ER El Omar, EM Belz, GT Hansbro, PM

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Allergy, 2020
Issue Date:: 2020-08-06

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Field	Value	Language
dc.contributor.author	Alemao, CA
dc.contributor.author	Budden, KF
dc.contributor.author	Gomez, HM
dc.contributor.author	Rehman, SF
dc.contributor.author	Marshall, JE
dc.contributor.author	Shukla, SD
dc.contributor.author	Donovan, C https://orcid.org/0000-0003-4558-329X
dc.contributor.author	Forster, SC
dc.contributor.author	Yang, IA
dc.contributor.author	Keely, S
dc.contributor.author	Mann, ER
dc.contributor.author	El Omar, EM
dc.contributor.author	Belz, GT
dc.contributor.author	Hansbro, PM
dc.date.accessioned	2020-12-16T01:39:02Z
dc.date.available	2020-07-30
dc.date.available	2020-12-16T01:39:02Z
dc.date.issued	2020-08-06
dc.identifier.citation	Allergy, 2020
dc.identifier.issn	0105-4538
dc.identifier.issn	1398-9995
dc.identifier.uri	http://hdl.handle.net/10453/144742
dc.description.abstract	The prevalence of chronic immune and metabolic disorders is increasing rapidly. In particular, inflammatory bowel diseases, obesity, diabetes, asthma and chronic obstructive pulmonary disease have become major healthcare and economic burdens worldwide. Recent advances in microbiome research have led to significant discoveries of associative links between alterations in the microbiome and health, as well as these chronic supposedly noncommunicable, immune/metabolic disorders. Importantly, the interplay between diet, microbiome and the mucous barrier in these diseases has gained significant attention. Diet modulates the mucous barrier via alterations in gut microbiota, resulting in either disease onset/exacerbation due to a "poor" diet or protection against disease with a "healthy" diet. In addition, many mucosa-associated disorders possess a specific gut microbiome fingerprint associated with the composition of the mucous barrier, which is further influenced by host-microbiome and inter-microbial interactions, dietary choices, microbe immigration and antimicrobials. Our review focuses on the interactions of diet (macronutrients and micronutrients), gut microbiota and mucous barriers (gastrointestinal and respiratory tract) and their importance in the onset and/or progression of major immune/metabolic disorders. We also highlight the key mechanisms that could be targeted therapeutically to prevent and/or treat these disorders.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1079187
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation.ispartof	Allergy
dc.relation.isbasedon	10.1111/all.14548
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1107 Immunology
dc.subject.classification	Allergy
dc.title	Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders.
dc.type	Journal Article
utslib.location.activity	Denmark
utslib.for	1107 Immunology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2020-12-16T01:38:49Z
pubs.publication-status	Published

Abstract:

The prevalence of chronic immune and metabolic disorders is increasing rapidly. In particular, inflammatory bowel diseases, obesity, diabetes, asthma and chronic obstructive pulmonary disease have become major healthcare and economic burdens worldwide. Recent advances in microbiome research have led to significant discoveries of associative links between alterations in the microbiome and health, as well as these chronic supposedly noncommunicable, immune/metabolic disorders. Importantly, the interplay between diet, microbiome and the mucous barrier in these diseases has gained significant attention. Diet modulates the mucous barrier via alterations in gut microbiota, resulting in either disease onset/exacerbation due to a "poor" diet or protection against disease with a "healthy" diet. In addition, many mucosa-associated disorders possess a specific gut microbiome fingerprint associated with the composition of the mucous barrier, which is further influenced by host-microbiome and inter-microbial interactions, dietary choices, microbe immigration and antimicrobials. Our review focuses on the interactions of diet (macronutrients and micronutrients), gut microbiota and mucous barriers (gastrointestinal and respiratory tract) and their importance in the onset and/or progression of major immune/metabolic disorders. We also highlight the key mechanisms that could be targeted therapeutically to prevent and/or treat these disorders.

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http://hdl.handle.net/10453/144742