Large Extracellular Cord Formation in a Zebrafish Model of Mycobacterium kansasii Infection.

Johansen, MD; Kremer, L

Large Extracellular Cord Formation in a Zebrafish Model of Mycobacterium kansasii Infection.

Johansen, MD Kremer, L

Permalink

Publisher:: Oxford University Press (OUP)
Publication Type:: Journal Article
Citation:: The Journal of infectious diseases, 2020, 222, (6), pp. 1046-1050
Issue Date:: 2020-08

Closed Access

	Filename	Description	Size
	jiaa187.pdf	Published version	6.22 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Johansen, MD
dc.contributor.author	Kremer, L
dc.date.accessioned	2020-12-17T02:29:44Z
dc.date.available	2020-04-14
dc.date.available	2020-12-17T02:29:44Z
dc.date.issued	2020-08
dc.identifier.citation	The Journal of infectious diseases, 2020, 222, (6), pp. 1046-1050
dc.identifier.issn	1537-6613
dc.identifier.issn	1537-6613
dc.identifier.uri	http://hdl.handle.net/10453/144794
dc.description.abstract	Mycobacterium kansasii is a slow-growing nontuberculous mycobacteria responsible for coinfections particularly in patients with human immunodeficiency virus. To date, our knowledge of M. kansasii infection has been hampered owing to the lack of an effective animal model to study pathogenesis. In the current study, we showed that the zebrafish embryo is permissive to M. kansasii infection, resulting in chronic infection and formation of granulomas. On macrophage depletion, we identified M. kansasii forms extracellular cords, resulting in acute infection and rapid larval death. These findings highlight the feasibility of zebrafish for studying M. kansasii pathogenesis and for the first time identify extracellular cords in this species.
dc.format	Print
dc.language	eng
dc.publisher	Oxford University Press (OUP)
dc.relation.ispartof	The Journal of infectious diseases
dc.relation.isbasedon	10.1093/infdis/jiaa187
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences
dc.subject.classification	Microbiology
dc.title	Large Extracellular Cord Formation in a Zebrafish Model of Mycobacterium kansasii Infection.
dc.type	Journal Article
utslib.citation.volume	222
utslib.location.activity	United States
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2020-12-17T02:29:36Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	222
utslib.citation.issue	6

Abstract:

Mycobacterium kansasii is a slow-growing nontuberculous mycobacteria responsible for coinfections particularly in patients with human immunodeficiency virus. To date, our knowledge of M. kansasii infection has been hampered owing to the lack of an effective animal model to study pathogenesis. In the current study, we showed that the zebrafish embryo is permissive to M. kansasii infection, resulting in chronic infection and formation of granulomas. On macrophage depletion, we identified M. kansasii forms extracellular cords, resulting in acute infection and rapid larval death. These findings highlight the feasibility of zebrafish for studying M. kansasii pathogenesis and for the first time identify extracellular cords in this species.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/144794