Medial Orbitofrontal Cortex Regulates Instrumental Conditioned Punishment, but not Pavlovian Conditioned Fear

Ma, C; Jean-Richard-dit-Bressel, P; Roughley, S; Vissel, B; Balleine, BW; Killcross, S; Bradfield, LA

Medial Orbitofrontal Cortex Regulates Instrumental Conditioned Punishment, but not Pavlovian Conditioned Fear

Ma, C Jean-Richard-dit-Bressel, P Roughley, S Vissel, B

Balleine, BW Killcross, S Bradfield, LA

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Publisher:: Oxford University Press (OUP)
Publication Type:: Journal Article
Citation:: Cerebral Cortex Communications, 2020, 1, (1), pp. 1-13
Issue Date:: 2020-01-01

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Field	Value	Language
dc.contributor.author	Ma, C
dc.contributor.author	Jean-Richard-dit-Bressel, P
dc.contributor.author	Roughley, S
dc.contributor.author	Vissel, B https://orcid.org/0000-0001-8860-8050
dc.contributor.author	Balleine, BW
dc.contributor.author	Killcross, S
dc.contributor.author	Bradfield, LA
dc.date.accessioned	2020-12-18T02:41:09Z
dc.date.available	2020-12-18T02:41:09Z
dc.date.issued	2020-01-01
dc.identifier.citation	Cerebral Cortex Communications, 2020, 1, (1), pp. 1-13
dc.identifier.issn	2632-7376
dc.identifier.issn	2632-7376
dc.identifier.uri	http://hdl.handle.net/10453/144837
dc.description.abstract	<jats:title>Abstract</jats:title> <jats:p>Bidirectionally aberrant medial orbitofrontal cortical (mOFC) activity has been consistently linked with compulsive disorders and related behaviors. Although rodent studies have established a causal link between mOFC excitation and compulsive-like actions, no such link has been made with mOFC inhibition. Here we use excitotoxic lesions of mOFC to investigate its role in sensitivity to punishment; a core characteristic of many compulsive disorders. In our first experiment, we demonstrated that mOFC lesions prevented rats from learning to avoid a lever that was punished with a stimulus that co-terminated with footshock. Our second experiment demonstrated that retrieval of punishment learning is also somewhat mOFC-dependent, as lesions prevented the extended retrieval of punishment contingencies relative to shams. In contrast, mOFC lesions did not prevent rats from re-acquiring the ability to avoid a punished lever when it was learned prior to lesions being administered. In both experiments, Pavlovian fear conditioning to the stimulus was intact for all animals. Together, these results reveal that the mOFC regulates punishment learning and retrieval in a manner that is separate from any role in Pavlovian fear conditioning. These results imply that aberrant mOFC activity may contribute to the punishment insensitivity that is observed across multiple compulsive disorders.</jats:p>
dc.language	en
dc.publisher	Oxford University Press (OUP)
dc.relation	http://purl.org/au-research/grants/arc/DP200102445
dc.relation.ispartof	Cerebral Cortex Communications
dc.relation.isbasedon	10.1093/texcom/tgaa039
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Medial Orbitofrontal Cortex Regulates Instrumental Conditioned Punishment, but not Pavlovian Conditioned Fear
dc.type	Journal Article
utslib.citation.volume	1
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2020-12-18T02:40:54Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	1
utslib.citation.issue	1

Abstract:

Abstract Bidirectionally aberrant medial orbitofrontal cortical (mOFC) activity has been consistently linked with compulsive disorders and related behaviors. Although rodent studies have established a causal link between mOFC excitation and compulsive-like actions, no such link has been made with mOFC inhibition. Here we use excitotoxic lesions of mOFC to investigate its role in sensitivity to punishment; a core characteristic of many compulsive disorders. In our first experiment, we demonstrated that mOFC lesions prevented rats from learning to avoid a lever that was punished with a stimulus that co-terminated with footshock. Our second experiment demonstrated that retrieval of punishment learning is also somewhat mOFC-dependent, as lesions prevented the extended retrieval of punishment contingencies relative to shams. In contrast, mOFC lesions did not prevent rats from re-acquiring the ability to avoid a punished lever when it was learned prior to lesions being administered. In both experiments, Pavlovian fear conditioning to the stimulus was intact for all animals. Together, these results reveal that the mOFC regulates punishment learning and retrieval in a manner that is separate from any role in Pavlovian fear conditioning. These results imply that aberrant mOFC activity may contribute to the punishment insensitivity that is observed across multiple compulsive disorders.

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http://hdl.handle.net/10453/144837