Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease.
Horvat, JC
Beagley, KW
Wade, MA
Preston, JA
Hansbro, NG
Hickey, DK
Kaiko, GE
Gibson, PG
Foster, PS
Hansbro, PM
- Publisher:
- AMER THORACIC SOC
- Publication Type:
- Journal Article
- Citation:
- American journal of respiratory and critical care medicine, 2007, 176, (6), pp. 556-564
- Issue Date:
- 2007-09
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Neonatal Chlamydial infection induces mixed T-cell responses that drive allergic airway disease.pdf | Accepted version | 303.19 kB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Horvat, JC | |
dc.contributor.author | Beagley, KW | |
dc.contributor.author | Wade, MA | |
dc.contributor.author | Preston, JA | |
dc.contributor.author | Hansbro, NG | |
dc.contributor.author | Hickey, DK | |
dc.contributor.author | Kaiko, GE | |
dc.contributor.author | Gibson, PG | |
dc.contributor.author | Foster, PS | |
dc.contributor.author | Hansbro, PM | |
dc.date.accessioned | 2020-12-22T22:55:54Z | |
dc.date.available | 2020-12-22T22:55:54Z | |
dc.date.issued | 2007-09 | |
dc.identifier.citation | American journal of respiratory and critical care medicine, 2007, 176, (6), pp. 556-564 | |
dc.identifier.issn | 1073-449X | |
dc.identifier.issn | 1535-4970 | |
dc.identifier.uri | http://hdl.handle.net/10453/144914 | |
dc.description.abstract | RATIONALE: Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown. OBJECTIVES: To determine the effect of chlamydial infection at various ages on the development of allergic airway disease (AAD). METHODS: Mouse models of chlamydial lung infection and ovalbumin-induced AAD were established in neonatal and adult BALB/c mice. Neonatal or adult mice were given a chlamydial infection and 6 weeks later were sensitized and subsequently challenged with ovalbumin. Features of AAD and inflammation were compared between uninfected or unsensitized controls. MEASUREMENTS AND MAIN RESULTS: Mild Chlamydia-induced lung disease was observed 10-15 days after infection, as evidenced by increased bacterial numbers and histopathology in the lung and a reduction in weight gain. After 6 weeks, infection and histopathology had resolved and the rate of weight gain had recovered. Neonatal but not adult infection resulted in significant decreases in interleukin-5 production from helper T cells and by the numbers of eosinophils recruited to the lung in response to ovalbumin exposure. Remarkably, the effects of early-life infection were associated with the generation of both type 1 and 2 ovalbumin-specific helper T-cell cytokine and antibody responses. Furthermore, although neonatal infection significantly attenuated eosinophilia, the generation of the mixed T-cell response exacerbated other hallmark features of asthma: mucus hypersecretion and airway hyperresponsiveness. Moreover, infection prolonged the expression of AAD and these effects were restricted to early-life infection. CONCLUSIONS: Early-life chlamydial infection induces a mixed type 1 and 2 T-cell response to antigen, which differentially affects the development of key features of AAD in the adult. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | AMER THORACIC SOC | |
dc.relation.ispartof | American journal of respiratory and critical care medicine | |
dc.relation.isbasedon | 10.1164/rccm.200607-1005oc | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 11 Medical and Health Sciences | |
dc.subject.classification | Respiratory System | |
dc.subject.mesh | T-Lymphocytes | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Mice, Inbred BALB C | |
dc.subject.mesh | Animals, Newborn | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Chlamydia | |
dc.subject.mesh | Chlamydia Infections | |
dc.subject.mesh | Asthma | |
dc.subject.mesh | Disease Models, Animal | |
dc.subject.mesh | Disease Progression | |
dc.subject.mesh | Cytokines | |
dc.subject.mesh | Prognosis | |
dc.subject.mesh | Colony Count, Microbial | |
dc.subject.mesh | Follow-Up Studies | |
dc.subject.mesh | Immunity, Cellular | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Female | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Animals, Newborn | |
dc.subject.mesh | Asthma | |
dc.subject.mesh | Chlamydia | |
dc.subject.mesh | Chlamydia Infections | |
dc.subject.mesh | Colony Count, Microbial | |
dc.subject.mesh | Cytokines | |
dc.subject.mesh | Disease Models, Animal | |
dc.subject.mesh | Disease Progression | |
dc.subject.mesh | Female | |
dc.subject.mesh | Follow-Up Studies | |
dc.subject.mesh | Immunity, Cellular | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Mice, Inbred BALB C | |
dc.subject.mesh | Pregnancy | |
dc.subject.mesh | Prognosis | |
dc.subject.mesh | T-Lymphocytes | |
dc.title | Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease. | |
dc.type | Journal Article | |
utslib.citation.volume | 176 | |
utslib.location.activity | United States | |
utslib.for | 11 Medical and Health Sciences | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2020-12-22T22:55:43Z | |
pubs.issue | 6 | |
pubs.publication-status | Published | |
pubs.volume | 176 | |
utslib.citation.issue | 6 |
Abstract:
RATIONALE: Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown. OBJECTIVES: To determine the effect of chlamydial infection at various ages on the development of allergic airway disease (AAD). METHODS: Mouse models of chlamydial lung infection and ovalbumin-induced AAD were established in neonatal and adult BALB/c mice. Neonatal or adult mice were given a chlamydial infection and 6 weeks later were sensitized and subsequently challenged with ovalbumin. Features of AAD and inflammation were compared between uninfected or unsensitized controls. MEASUREMENTS AND MAIN RESULTS: Mild Chlamydia-induced lung disease was observed 10-15 days after infection, as evidenced by increased bacterial numbers and histopathology in the lung and a reduction in weight gain. After 6 weeks, infection and histopathology had resolved and the rate of weight gain had recovered. Neonatal but not adult infection resulted in significant decreases in interleukin-5 production from helper T cells and by the numbers of eosinophils recruited to the lung in response to ovalbumin exposure. Remarkably, the effects of early-life infection were associated with the generation of both type 1 and 2 ovalbumin-specific helper T-cell cytokine and antibody responses. Furthermore, although neonatal infection significantly attenuated eosinophilia, the generation of the mixed T-cell response exacerbated other hallmark features of asthma: mucus hypersecretion and airway hyperresponsiveness. Moreover, infection prolonged the expression of AAD and these effects were restricted to early-life infection. CONCLUSIONS: Early-life chlamydial infection induces a mixed type 1 and 2 T-cell response to antigen, which differentially affects the development of key features of AAD in the adult.
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