Rationale and design of a randomized controlled trial of pneumococcal polysaccharide vaccine for prevention of cardiovascular events: The Australian Study for the Prevention through Immunization of Cardiovascular Events (AUSPICE).

Ren, S; Hure, A; Peel, R; D'Este, C; Abhayaratna, W; Tonkin, A; Hopper, I; Thrift, AG; Levi, C; Sturm, J; Durrheim, D; Hung, J; Briffa, T; Chew, DP; Anderson, P; Moon, L; McEvoy, M; Hansbro, P; Newby, D; Attia, J; AUSPICE study group

Rationale and design of a randomized controlled trial of pneumococcal polysaccharide vaccine for prevention of cardiovascular events: The Australian Study for the Prevention through Immunization of Cardiovascular Events (AUSPICE).

Ren, S Hure, A Peel, R D'Este, C Abhayaratna, W Tonkin, A Hopper, I Thrift, AG Levi, C Sturm, J Durrheim, D Hung, J Briffa, T Chew, DP Anderson, P Moon, L McEvoy, M Hansbro, P

Newby, D Attia, J AUSPICE study group

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Publisher:: MOSBY-ELSEVIER
Publication Type:: Journal Article
Citation:: American heart journal, 2016, 177, pp. 58-65
Issue Date:: 2016-07

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Field	Value	Language
dc.contributor.author	Ren, S
dc.contributor.author	Hure, A
dc.contributor.author	Peel, R
dc.contributor.author	D'Este, C
dc.contributor.author	Abhayaratna, W
dc.contributor.author	Tonkin, A
dc.contributor.author	Hopper, I
dc.contributor.author	Thrift, AG
dc.contributor.author	Levi, C
dc.contributor.author	Sturm, J
dc.contributor.author	Durrheim, D
dc.contributor.author	Hung, J
dc.contributor.author	Briffa, T
dc.contributor.author	Chew, DP
dc.contributor.author	Anderson, P
dc.contributor.author	Moon, L
dc.contributor.author	McEvoy, M
dc.contributor.author	Hansbro, P https://orcid.org/0000-0002-4741-3035
dc.contributor.author	Newby, D
dc.contributor.author	Attia, J
dc.contributor.author	AUSPICE study group
dc.date.accessioned	2021-01-04T23:06:37Z
dc.date.available	2016-04-12
dc.date.available	2021-01-04T23:06:37Z
dc.date.issued	2016-07
dc.identifier.citation	American heart journal, 2016, 177, pp. 58-65
dc.identifier.issn	0002-8703
dc.identifier.issn	1097-6744
dc.identifier.uri	http://hdl.handle.net/10453/145073
dc.description.abstract	Research has shown that vaccination with Streptococcus pneumoniae reduced the extent of atherosclerosis in experimental animal models. It is thought that phosphorylcholine lipid antigens in the S. pneumoniae cell wall induce the production of antibodies that cross-react with oxidized low-density lipoprotein, a component of atherosclerotic plaques. These antibodies may bind to and facilitate the regression of the plaques. Available data provide evidence that similar mechanisms also occur in humans, leading to the possibility that pneumococcal vaccination protects against atherosclerosis. A systematic review and meta-analysis, including 8 observational human studies, of adult pneumococcal polysaccharide vaccination for preventing cardiovascular disease in people older than 65 years, showed a 17% reduction in the odds (odds ratio 0.83, 95% CI 0.71-0.97) of having an acute coronary syndrome event.The AUSPICE is a multicenter, randomized, placebo-controlled, double-blind, clinical trial to formally test whether vaccination with the pneumococcal polysaccharide vaccine protects against cardiovascular events (fatal and nonfatal acute coronary syndromes and ischemic strokes). Cardiovascular outcomes will be obtained during 4 to 5 years of follow-up, through health record linkage with state and national administrative data sets.This is the first registered randomized controlled trial (on US, World Health Organization, Australia and New Zealand trial registries) to be conducted to test whether vaccination with the pneumococcal polysaccharide vaccine will reduce cardiovascular events. If successful, vaccination can be readily extended to at-risk groups to reduce the risk of cardiovascular diseases.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	MOSBY-ELSEVIER
dc.relation.ispartof	American heart journal
dc.relation.isbasedon	10.1016/j.ahj.2016.04.003
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1102 Cardiorespiratory Medicine and Haematology, 1117 Public Health and Health Services
dc.subject.classification	Cardiovascular System & Hematology
dc.subject.mesh	Humans
dc.subject.mesh	Carotid Artery Diseases
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Lipoproteins, LDL
dc.subject.mesh	Pneumococcal Vaccines
dc.subject.mesh	Antibodies, Bacterial
dc.subject.mesh	Odds Ratio
dc.subject.mesh	Double-Blind Method
dc.subject.mesh	Cross Reactions
dc.subject.mesh	Middle Aged
dc.subject.mesh	Australia
dc.subject.mesh	Atherosclerosis
dc.subject.mesh	Stroke
dc.subject.mesh	Acute Coronary Syndrome
dc.subject.mesh	Carotid Intima-Media Thickness
dc.subject.mesh	Pulse Wave Analysis
dc.subject.mesh	Acute Coronary Syndrome
dc.subject.mesh	Antibodies, Bacterial
dc.subject.mesh	Atherosclerosis
dc.subject.mesh	Australia
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Carotid Artery Diseases
dc.subject.mesh	Carotid Intima-Media Thickness
dc.subject.mesh	Cross Reactions
dc.subject.mesh	Double-Blind Method
dc.subject.mesh	Humans
dc.subject.mesh	Lipoproteins, LDL
dc.subject.mesh	Middle Aged
dc.subject.mesh	Odds Ratio
dc.subject.mesh	Pneumococcal Vaccines
dc.subject.mesh	Pulse Wave Analysis
dc.subject.mesh	Stroke
dc.title	Rationale and design of a randomized controlled trial of pneumococcal polysaccharide vaccine for prevention of cardiovascular events: The Australian Study for the Prevention through Immunization of Cardiovascular Events (AUSPICE).
dc.type	Journal Article
utslib.citation.volume	177
utslib.location.activity	United States
utslib.for	1102 Cardiorespiratory Medicine and Haematology
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2021-01-04T23:06:30Z
pubs.publication-status	Published
pubs.volume	177

Abstract:

Research has shown that vaccination with Streptococcus pneumoniae reduced the extent of atherosclerosis in experimental animal models. It is thought that phosphorylcholine lipid antigens in the S. pneumoniae cell wall induce the production of antibodies that cross-react with oxidized low-density lipoprotein, a component of atherosclerotic plaques. These antibodies may bind to and facilitate the regression of the plaques. Available data provide evidence that similar mechanisms also occur in humans, leading to the possibility that pneumococcal vaccination protects against atherosclerosis. A systematic review and meta-analysis, including 8 observational human studies, of adult pneumococcal polysaccharide vaccination for preventing cardiovascular disease in people older than 65 years, showed a 17% reduction in the odds (odds ratio 0.83, 95% CI 0.71-0.97) of having an acute coronary syndrome event.The AUSPICE is a multicenter, randomized, placebo-controlled, double-blind, clinical trial to formally test whether vaccination with the pneumococcal polysaccharide vaccine protects against cardiovascular events (fatal and nonfatal acute coronary syndromes and ischemic strokes). Cardiovascular outcomes will be obtained during 4 to 5 years of follow-up, through health record linkage with state and national administrative data sets.This is the first registered randomized controlled trial (on US, World Health Organization, Australia and New Zealand trial registries) to be conducted to test whether vaccination with the pneumococcal polysaccharide vaccine will reduce cardiovascular events. If successful, vaccination can be readily extended to at-risk groups to reduce the risk of cardiovascular diseases.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/145073