Specifiable biomimetic microsponges for timed release of crystal entrapped biomolecules useful in bone repair.

Green, DW; Green, DW; Stamboulis, A; Ben-Nissan, B

Specifiable biomimetic microsponges for timed release of crystal entrapped biomolecules useful in bone repair.

Green, DW Green, DW Stamboulis, A Ben-Nissan, B

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Publisher:: Royal Society of Chemistry (RSC)
Publication Type:: Journal Article
Citation:: Journal of materials chemistry. B, 2020, 8, (32), pp. 7143-7148
Issue Date:: 2020-08

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Field	Value	Language
dc.contributor.author	Green, DW
dc.contributor.author	Green, DW
dc.contributor.author	Stamboulis, A
dc.contributor.author	Ben-Nissan, B
dc.date.accessioned	2021-01-08T02:55:39Z
dc.date.available	2021-01-08T02:55:39Z
dc.date.issued	2020-08
dc.identifier.citation	Journal of materials chemistry. B, 2020, 8, (32), pp. 7143-7148
dc.identifier.issn	2050-750X
dc.identifier.issn	2050-7518
dc.identifier.uri	http://hdl.handle.net/10453/145213
dc.description.abstract	Most marine materials, by nature, contain crystals of inorganic matter with specific structures that allow the loading, release, and delivery of biomolecules that can be utilized in clinical applications. These structures can be biomimetically synthesized. Aggregates of inorganic particles generated by biomimetic microsponges may provide surfaces and structures for cell attachment, organization, and promotion of matrix synthesis. Biomimetic microsponges have been developed with tunable release profiles differing by the rate (speed over distance), velocity (rate of change in direction), and the quantity discharged over time, according to biomolecular species. Specifically, the types of proteins involved guide and regulate cells in physical contact with the microsponges, for instance, reprogramming somatic cells, the switching phenotypes, or specifying stem cell differentiation. Applications for these microsponges include gene transfection of localized cells and promotion of bone matrix synthesis by the externalized display of RGD cell adhesive peptides and the release of crystal entrapped, occluded, adsorbed and infused rhBMP-2 and plasmid. A requirement for de novo bone formation is a solid structure to enable osteocytes to lay new bone tissue. In this study, biomimetic microsponges highlight tremendous potential as osteoconductive packing material in bone repair with parallel influence on regeneration. Majorly, microsponges offer pronounced osteoinductivity, unlike many other bone particulates, by solid-state integration of active regenerative biological molecules through the prism of the biomineral crystalline structure.
dc.format	Print
dc.language	eng
dc.publisher	Royal Society of Chemistry (RSC)
dc.relation.ispartof	Journal of materials chemistry. B
dc.relation.isbasedon	10.1039/d0tb01491e
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0903 Biomedical Engineering
dc.title	Specifiable biomimetic microsponges for timed release of crystal entrapped biomolecules useful in bone repair.
dc.type	Journal Article
utslib.citation.volume	8
utslib.location.activity	England
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0903 Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2021-01-08T02:55:21Z
pubs.issue	32
pubs.publication-status	Published
pubs.volume	8
utslib.citation.issue	32

Abstract:

Most marine materials, by nature, contain crystals of inorganic matter with specific structures that allow the loading, release, and delivery of biomolecules that can be utilized in clinical applications. These structures can be biomimetically synthesized. Aggregates of inorganic particles generated by biomimetic microsponges may provide surfaces and structures for cell attachment, organization, and promotion of matrix synthesis. Biomimetic microsponges have been developed with tunable release profiles differing by the rate (speed over distance), velocity (rate of change in direction), and the quantity discharged over time, according to biomolecular species. Specifically, the types of proteins involved guide and regulate cells in physical contact with the microsponges, for instance, reprogramming somatic cells, the switching phenotypes, or specifying stem cell differentiation. Applications for these microsponges include gene transfection of localized cells and promotion of bone matrix synthesis by the externalized display of RGD cell adhesive peptides and the release of crystal entrapped, occluded, adsorbed and infused rhBMP-2 and plasmid. A requirement for de novo bone formation is a solid structure to enable osteocytes to lay new bone tissue. In this study, biomimetic microsponges highlight tremendous potential as osteoconductive packing material in bone repair with parallel influence on regeneration. Majorly, microsponges offer pronounced osteoinductivity, unlike many other bone particulates, by solid-state integration of active regenerative biological molecules through the prism of the biomineral crystalline structure.

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http://hdl.handle.net/10453/145213