Self-detoxifying hollow zinc silica nanospheres with tunable Ag ion release-recapture capability: A nanoantibiotic for efficient MRSA inhibition

Wu, H; Tian, H; Li, J; Liu, L; Wang, Y; Qiu, J; Wang, S; Liu, S

Self-detoxifying hollow zinc silica nanospheres with tunable Ag ion release-recapture capability: A nanoantibiotic for efficient MRSA inhibition

Wu, H Tian, H

Li, J Liu, L Wang, Y Qiu, J Wang, S Liu, S

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Composites Part B: Engineering, 2020, 202
Issue Date:: 2020-12-01

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Field	Value	Language
dc.contributor.author	Wu, H
dc.contributor.author	Tian, H https://orcid.org/0000-0002-9581-0027
dc.contributor.author	Li, J
dc.contributor.author	Liu, L
dc.contributor.author	Wang, Y
dc.contributor.author	Qiu, J
dc.contributor.author	Wang, S
dc.contributor.author	Liu, S
dc.date.accessioned	2021-01-08T04:32:13Z
dc.date.available	2021-01-08T04:32:13Z
dc.date.issued	2020-12-01
dc.identifier.citation	Composites Part B: Engineering, 2020, 202
dc.identifier.issn	1359-8368
dc.identifier.issn	1359-8368
dc.identifier.uri	http://hdl.handle.net/10453/145227
dc.description.abstract	© 2020 Elsevier Ltd Nanoparticle-enabled strategies to combat antimicrobial-resistant (AMR) bacteria are highly demanded, which hopefully can overcome the barriers associated with conventional antibiotics to achieve high therapeutic efficacy by improving pharmacokinetics. Here, we report the controlled fabrication of multiple Ag nanoparticles (AgNPs) containing ZIF-8 derived hollow -Zn-O-Si- nanospheres with mesoporous wall, Ag&Zn@mesSiO2, which can release and recapture Ag+ ions, thus, efficiently eradicate planktonic methicillin-resistant Staphylococcus aureus (MRSA) in vivo. The AgNPs encapsulated inside the large internal cavities of the hollow structure can kill MRSA at significantly reduced dosages due to the synergistic effect of released Zn and Ag ions, which was 10 times lower in comparison with single Ag+ application. The boomerang-like release-and-recapture scheme of the Ag+ ions helps to greatly reduce the notorious Ag toxicity. Such novel structured nanocomposites with widened Ag therapeutic window possess great potential as nanoantibiotic for tackling MRSA infection.
dc.language	en
dc.publisher	Elsevier BV
dc.relation.ispartof	Composites Part B: Engineering
dc.relation.isbasedon	10.1016/j.compositesb.2020.108415
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	09 Engineering
dc.subject.classification	Materials
dc.title	Self-detoxifying hollow zinc silica nanospheres with tunable Ag ion release-recapture capability: A nanoantibiotic for efficient MRSA inhibition
dc.type	Journal Article
utslib.citation.volume	202
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-01-08T04:31:46Z
pubs.publication-status	Published
pubs.volume	202

Abstract:

© 2020 Elsevier Ltd Nanoparticle-enabled strategies to combat antimicrobial-resistant (AMR) bacteria are highly demanded, which hopefully can overcome the barriers associated with conventional antibiotics to achieve high therapeutic efficacy by improving pharmacokinetics. Here, we report the controlled fabrication of multiple Ag nanoparticles (AgNPs) containing ZIF-8 derived hollow -Zn-O-Si- nanospheres with mesoporous wall, Ag&Zn@mesSiO2, which can release and recapture Ag+ ions, thus, efficiently eradicate planktonic methicillin-resistant Staphylococcus aureus (MRSA) in vivo. The AgNPs encapsulated inside the large internal cavities of the hollow structure can kill MRSA at significantly reduced dosages due to the synergistic effect of released Zn and Ag ions, which was 10 times lower in comparison with single Ag+ application. The boomerang-like release-and-recapture scheme of the Ag+ ions helps to greatly reduce the notorious Ag toxicity. Such novel structured nanocomposites with widened Ag therapeutic window possess great potential as nanoantibiotic for tackling MRSA infection.

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http://hdl.handle.net/10453/145227