Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus.

Johansen, MD; Herrmann, J-L; Kremer, L

Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus.

Johansen, MD Herrmann, J-L Kremer, L

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Publisher:: NATURE PUBLISHING GROUP
Publication Type:: Journal Article
Citation:: Nature reviews. Microbiology, 2020, 18, (7), pp. 392-407
Issue Date:: 2020-07

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Field	Value	Language
dc.contributor.author	Johansen, MD
dc.contributor.author	Herrmann, J-L
dc.contributor.author	Kremer, L
dc.date.accessioned	2021-01-11T01:18:01Z
dc.date.available	2020-01-15
dc.date.available	2021-01-11T01:18:01Z
dc.date.issued	2020-07
dc.identifier.citation	Nature reviews. Microbiology, 2020, 18, (7), pp. 392-407
dc.identifier.issn	1740-1526
dc.identifier.issn	1740-1534
dc.identifier.uri	http://hdl.handle.net/10453/145270
dc.description.abstract	Infections caused by non-tuberculous mycobacteria (NTM) are increasing globally and are notoriously difficult to treat due to intrinsic resistance of these bacteria to many common antibiotics. NTM are diverse and ubiquitous in the environment, with only a few species causing serious and often opportunistic infections in humans, including Mycobacterium abscessus. This rapidly growing mycobacterium is one of the most commonly identified NTM species responsible for severe respiratory, skin and mucosal infections in humans. It is often regarded as one of the most antibiotic-resistant mycobacteria, leaving us with few therapeutic options. In this Review, we cover the proposed infection process of M. abscessus, its virulence factors and host interactions and highlight the commonalities and differences of M. abscessus with other NTM species. Finally, we discuss drug resistance mechanisms and future therapeutic options. Taken together, this knowledge is essential to further our understanding of this overlooked and neglected global threat.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	NATURE PUBLISHING GROUP
dc.relation.ispartof	Nature reviews. Microbiology
dc.relation.isbasedon	10.1038/s41579-020-0331-1
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0605 Microbiology, 1108 Medical Microbiology
dc.subject.classification	Microbiology
dc.subject.mesh	Humans
dc.subject.mesh	Lung Diseases
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Drug Resistance, Multiple, Bacterial
dc.subject.mesh	Mycobacterium Infections, Nontuberculous
dc.subject.mesh	Mycobacterium abscessus
dc.subject.mesh	Humans
dc.subject.mesh	Lung Diseases
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Drug Resistance, Multiple, Bacterial
dc.subject.mesh	Mycobacterium Infections, Nontuberculous
dc.subject.mesh	Mycobacterium abscessus
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Drug Resistance, Multiple, Bacterial
dc.subject.mesh	Humans
dc.subject.mesh	Lung Diseases
dc.subject.mesh	Mycobacterium Infections, Nontuberculous
dc.subject.mesh	Mycobacterium abscessus
dc.title	Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus.
dc.type	Journal Article
utslib.citation.volume	18
utslib.location.activity	England
utslib.for	0605 Microbiology
utslib.for	1108 Medical Microbiology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-01-11T01:17:31Z
pubs.issue	7
pubs.publication-status	Published
pubs.volume	18
utslib.citation.issue	7

Abstract:

Infections caused by non-tuberculous mycobacteria (NTM) are increasing globally and are notoriously difficult to treat due to intrinsic resistance of these bacteria to many common antibiotics. NTM are diverse and ubiquitous in the environment, with only a few species causing serious and often opportunistic infections in humans, including Mycobacterium abscessus. This rapidly growing mycobacterium is one of the most commonly identified NTM species responsible for severe respiratory, skin and mucosal infections in humans. It is often regarded as one of the most antibiotic-resistant mycobacteria, leaving us with few therapeutic options. In this Review, we cover the proposed infection process of M. abscessus, its virulence factors and host interactions and highlight the commonalities and differences of M. abscessus with other NTM species. Finally, we discuss drug resistance mechanisms and future therapeutic options. Taken together, this knowledge is essential to further our understanding of this overlooked and neglected global threat.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/145270