Porous Upconversion Nanostructures as Bimodal Biomedical Imaging Contrast Agents

Du, Z; Gupta, A; Clarke, C; Cappadona, M; Clases, D; Liu, D; Yang, Z; Karan, S; Price, WS; Xu, X

Porous Upconversion Nanostructures as Bimodal Biomedical Imaging Contrast Agents

Du, Z Gupta, A Clarke, C

Cappadona, M Clases, D

Liu, D Yang, Z Karan, S Price, WS Xu, X

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Publisher:: AMER CHEMICAL SOC
Publication Type:: Journal Article
Citation:: Journal of Physical Chemistry C, 2020, 124, (22), pp. 12168-12174
Issue Date:: 2020-06-04

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Field	Value	Language
dc.contributor.author	Du, Z
dc.contributor.author	Gupta, A
dc.contributor.author	Clarke, C https://orcid.org/0000-0001-7575-696X
dc.contributor.author	Cappadona, M
dc.contributor.author	Clases, D https://orcid.org/0000-0003-3880-9385
dc.contributor.author	Liu, D
dc.contributor.author	Yang, Z
dc.contributor.author	Karan, S
dc.contributor.author	Price, WS
dc.contributor.author	Xu, X https://orcid.org/0000-0002-2598-3766
dc.date.accessioned	2021-01-13T01:17:15Z
dc.date.available	2021-01-13T01:17:15Z
dc.date.issued	2020-06-04
dc.identifier.citation	Journal of Physical Chemistry C, 2020, 124, (22), pp. 12168-12174
dc.identifier.issn	1932-7447
dc.identifier.issn	1932-7455
dc.identifier.uri	http://hdl.handle.net/10453/145359
dc.description.abstract	Copyright © 2020 American Chemical Society. Lanthanide ion doped upconversion nanoparticles (UCNPs) hold great promise as multimodal contrast agents for a range of medical imaging techniques, including optical bioimaging (OBI), magnetic resonance imaging (MRI), and computed tomography (CT). However, it is challenging to obtain UCNPs with both maximal contrast enhancement effects for both OBI and MRI simultaneously owing to the dilemma in the size of UCNPs. UCNPs in large dimensions contain more photonic Ln ions and less surface defects, which is favored for high luminescent emissions, while small UCNPs with high specific surface areas allow a higher proportion of paramagnetic Ln ions to be more accessible to water molecules, which offers enhanced contrast in MRI. In this work, we report the novel design of core-porous shell UCNPs with both high luminescent emissions and magnetic relaxivities as potential dual-modal contrast agents. The core-porous shell UCNPs were fabricated via the selective etching of the inert shell of NaYF4: 30%Gd at the active core of NaYF4: 20%Yb, 1%Er. Their morphology and composition were carefully characterized using transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy, X-ray diffraction, and high resolution TEM. Their photoluminescent and magnetic resonance properties were experimentally determined and compared for the core, core-dense shell, and core-porous shell UCNPs. Core-porous shell UCNPs were found to display bright luminescence and superior MRI contrast enhancement, thus showing great potential as bimodal OBI and MRI contrast agents.
dc.language	English
dc.publisher	AMER CHEMICAL SOC
dc.relation	German Research Foundation417283954
dc.relation.ispartof	Journal of Physical Chemistry C
dc.relation.isbasedon	10.1021/acs.jpcc.0c03945
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	03 Chemical Sciences, 09 Engineering, 10 Technology
dc.subject.classification	Physical Chemistry
dc.title	Porous Upconversion Nanostructures as Bimodal Biomedical Imaging Contrast Agents
dc.type	Journal Article
utslib.citation.volume	124
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
utslib.for	10 Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-01-13T01:17:09Z
pubs.issue	22
pubs.publication-status	Published
pubs.volume	124
utslib.citation.issue	22

Abstract:

Copyright © 2020 American Chemical Society. Lanthanide ion doped upconversion nanoparticles (UCNPs) hold great promise as multimodal contrast agents for a range of medical imaging techniques, including optical bioimaging (OBI), magnetic resonance imaging (MRI), and computed tomography (CT). However, it is challenging to obtain UCNPs with both maximal contrast enhancement effects for both OBI and MRI simultaneously owing to the dilemma in the size of UCNPs. UCNPs in large dimensions contain more photonic Ln ions and less surface defects, which is favored for high luminescent emissions, while small UCNPs with high specific surface areas allow a higher proportion of paramagnetic Ln ions to be more accessible to water molecules, which offers enhanced contrast in MRI. In this work, we report the novel design of core-porous shell UCNPs with both high luminescent emissions and magnetic relaxivities as potential dual-modal contrast agents. The core-porous shell UCNPs were fabricated via the selective etching of the inert shell of NaYF4: 30%Gd at the active core of NaYF4: 20%Yb, 1%Er. Their morphology and composition were carefully characterized using transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy, X-ray diffraction, and high resolution TEM. Their photoluminescent and magnetic resonance properties were experimentally determined and compared for the core, core-dense shell, and core-porous shell UCNPs. Core-porous shell UCNPs were found to display bright luminescence and superior MRI contrast enhancement, thus showing great potential as bimodal OBI and MRI contrast agents.

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http://hdl.handle.net/10453/145359