ICP-MS-Based strategies for protein quantification

John Wiley & Sons, Inc.
Publication Type:
Journal Article
Mass Spectrometry Reviews, 2010, 29 (2), pp. 326 - 348
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In the post-genomics era, proteomics has become a central branch in life sciences. An understanding of biological functions will not only rely on protein identification, but also on protein quantification in a living organism. Most of the existing methods for quantitative proteomics are based on isotope labeling combined with molecular mass spectrometry. Recently, a remarkable progress that utilizes inductively coupled plasmamass spectrometry (ICP-MS) as an attractive complement to electrospray MS and MALDI MS for protein quantification, especially for absolute quantification, has been achieved. This review will selectively discuss the recent advances of ICP-MSbased technique, which will be expected to further mature and to become one of the key methods in quantitative proteomics.
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