Airway epithelial regulation of pulmonary immune homeostasis and inflammation.

Hallstrand, TS; Hackett, TL; Altemeier, WA; Matute-Bello, G; Hansbro, PM; Knight, DA

Airway epithelial regulation of pulmonary immune homeostasis and inflammation.

Hallstrand, TS Hackett, TL Altemeier, WA Matute-Bello, G Hansbro, PM Knight, DA

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Publisher:: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Type:: Journal Article
Citation:: Clinical immunology (Orlando, Fla.), 2014, 151, (1), pp. 1-15
Issue Date:: 2014-03

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Field	Value	Language
dc.contributor.author	Hallstrand, TS
dc.contributor.author	Hackett, TL
dc.contributor.author	Altemeier, WA
dc.contributor.author	Matute-Bello, G
dc.contributor.author	Hansbro, PM
dc.contributor.author	Knight, DA
dc.date.accessioned	2021-03-03T23:38:55Z
dc.date.available	2013-12-04
dc.date.available	2021-03-03T23:38:55Z
dc.date.issued	2014-03
dc.identifier.citation	Clinical immunology (Orlando, Fla.), 2014, 151, (1), pp. 1-15
dc.identifier.issn	1521-6616
dc.identifier.issn	1521-7035
dc.identifier.uri	http://hdl.handle.net/10453/146732
dc.description.abstract	Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartof	Clinical immunology (Orlando, Fla.)
dc.relation.isbasedon	10.1016/j.clim.2013.12.003
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1107 Immunology
dc.subject.classification	Immunology
dc.subject.mesh	Lung
dc.subject.mesh	Respiratory Mucosa
dc.subject.mesh	Humans
dc.subject.mesh	Tobacco
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive
dc.subject.mesh	Bacterial Proteins
dc.subject.mesh	Chemokines, CC
dc.subject.mesh	Interleukins
dc.subject.mesh	Interleukin-17
dc.subject.mesh	Cytokines
dc.subject.mesh	Air Pollutants
dc.subject.mesh	Smoke
dc.subject.mesh	Homeostasis
dc.subject.mesh	Immunity, Innate
dc.subject.mesh	Adaptive Immunity
dc.subject.mesh	Interleukin-33
dc.subject.mesh	Adaptive Immunity
dc.subject.mesh	Air Pollutants
dc.subject.mesh	Bacterial Proteins
dc.subject.mesh	Chemokines, CC
dc.subject.mesh	Cytokines
dc.subject.mesh	Homeostasis
dc.subject.mesh	Humans
dc.subject.mesh	Immunity, Innate
dc.subject.mesh	Interleukin-17
dc.subject.mesh	Interleukin-33
dc.subject.mesh	Interleukins
dc.subject.mesh	Lung
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive
dc.subject.mesh	Respiratory Mucosa
dc.subject.mesh	Smoke
dc.subject.mesh	Tobacco
dc.title	Airway epithelial regulation of pulmonary immune homeostasis and inflammation.
dc.type	Journal Article
utslib.citation.volume	151
utslib.location.activity	United States
utslib.for	1107 Immunology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2021-03-03T23:38:53Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	151
utslib.citation.issue	1

Abstract:

Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/146732