Airway epithelial regulation of pulmonary immune homeostasis and inflammation.
- Publisher:
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Publication Type:
- Journal Article
- Citation:
- Clinical immunology (Orlando, Fla.), 2014, 151, (1), pp. 1-15
- Issue Date:
- 2014-03
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| Filename | Description | Size | |||
|---|---|---|---|---|---|
| Airway epithelial regulation of pulmonary immune homeostasis and inflammation.pdf | Published version | 854.12 kB | Adobe PDF |
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Full metadata record
| Field | Value | Language |
|---|---|---|
| dc.contributor.author | Hallstrand, TS | |
| dc.contributor.author | Hackett, TL | |
| dc.contributor.author | Altemeier, WA | |
| dc.contributor.author | Matute-Bello, G | |
| dc.contributor.author | Hansbro, PM | |
| dc.contributor.author | Knight, DA | |
| dc.date.accessioned | 2021-03-03T23:38:55Z | |
| dc.date.available | 2013-12-04 | |
| dc.date.available | 2021-03-03T23:38:55Z | |
| dc.date.issued | 2014-03 | |
| dc.identifier.citation | Clinical immunology (Orlando, Fla.), 2014, 151, (1), pp. 1-15 | |
| dc.identifier.issn | 1521-6616 | |
| dc.identifier.issn | 1521-7035 | |
| dc.identifier.uri | http://hdl.handle.net/10453/146732 | |
| dc.description.abstract | Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases. | |
| dc.format | Print-Electronic | |
| dc.language | eng | |
| dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | |
| dc.relation.ispartof | Clinical immunology (Orlando, Fla.) | |
| dc.relation.isbasedon | 10.1016/j.clim.2013.12.003 | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | 1107 Immunology | |
| dc.subject.classification | Immunology | |
| dc.subject.mesh | Lung | |
| dc.subject.mesh | Respiratory Mucosa | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Tobacco | |
| dc.subject.mesh | Pulmonary Disease, Chronic Obstructive | |
| dc.subject.mesh | Bacterial Proteins | |
| dc.subject.mesh | Chemokines, CC | |
| dc.subject.mesh | Interleukins | |
| dc.subject.mesh | Interleukin-17 | |
| dc.subject.mesh | Cytokines | |
| dc.subject.mesh | Air Pollutants | |
| dc.subject.mesh | Smoke | |
| dc.subject.mesh | Homeostasis | |
| dc.subject.mesh | Immunity, Innate | |
| dc.subject.mesh | Adaptive Immunity | |
| dc.subject.mesh | Interleukin-33 | |
| dc.subject.mesh | Adaptive Immunity | |
| dc.subject.mesh | Air Pollutants | |
| dc.subject.mesh | Bacterial Proteins | |
| dc.subject.mesh | Chemokines, CC | |
| dc.subject.mesh | Cytokines | |
| dc.subject.mesh | Homeostasis | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Immunity, Innate | |
| dc.subject.mesh | Interleukin-17 | |
| dc.subject.mesh | Interleukin-33 | |
| dc.subject.mesh | Interleukins | |
| dc.subject.mesh | Lung | |
| dc.subject.mesh | Pulmonary Disease, Chronic Obstructive | |
| dc.subject.mesh | Respiratory Mucosa | |
| dc.subject.mesh | Smoke | |
| dc.subject.mesh | Tobacco | |
| dc.title | Airway epithelial regulation of pulmonary immune homeostasis and inflammation. | |
| dc.type | Journal Article | |
| utslib.citation.volume | 151 | |
| utslib.location.activity | United States | |
| utslib.for | 1107 Immunology | |
| pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
| pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
| pubs.organisational-group | /University of Technology Sydney | |
| utslib.copyright.status | closed_access | * |
| dc.date.updated | 2021-03-03T23:38:53Z | |
| pubs.issue | 1 | |
| pubs.publication-status | Published | |
| pubs.volume | 151 | |
| utslib.citation.issue | 1 |
Abstract:
Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases.
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