Generation of Cerebral Cavernous Malformation in Neonatal Mouse Models Using Inducible Cre-LoxP Strategy.

Choi, JP; Zheng, X

Generation of Cerebral Cavernous Malformation in Neonatal Mouse Models Using Inducible Cre-LoxP Strategy.

Choi, JP Zheng, X

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Publisher:: Springer US
Publication Type:: Chapter
Citation:: Methods in Molecular Biology, 2020, 2152, pp. 253-258
Issue Date:: 2020-01

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Field	Value	Language
dc.contributor.author	Choi, JP
dc.contributor.author	Zheng, X
dc.date.accessioned	2021-03-09T22:55:56Z
dc.date.available	2021-03-09T22:55:56Z
dc.date.issued	2020-01
dc.identifier.citation	Methods in Molecular Biology, 2020, 2152, pp. 253-258
dc.identifier.isbn	9781071606391
dc.identifier.uri	http://hdl.handle.net/10453/146973
dc.description.abstract	Mutations in the CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation (CCM) in humans. Neonatal mouse models of CCM disease have been established by deleting any one of the Ccm genes. These mouse models provide invaluable in vivo disease model to investigate molecular mechanisms and therapeutic approaches for the disease. Here, we describe detailed methodology to generate CCM disease in mouse models (Ccm1 and Ccm2-deficient) using inducible Cre/loxP recombination strategy.
dc.format	Print
dc.language	en
dc.publisher	Springer US
dc.relation.ispartof	Methods in Molecular Biology
dc.relation.isbasedon	10.1007/978-1-0716-0640-7_18
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0399 Other Chemical Sciences, 0601 Biochemistry and Cell Biology
dc.subject.classification	Developmental Biology
dc.title	Generation of Cerebral Cavernous Malformation in Neonatal Mouse Models Using Inducible Cre-LoxP Strategy.
dc.type	Chapter
utslib.citation.volume	2152
utslib.for	0399 Other Chemical Sciences
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2021-03-09T22:55:54Z
pubs.publication-status	Published
pubs.volume	2152

Abstract:

Mutations in the CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation (CCM) in humans. Neonatal mouse models of CCM disease have been established by deleting any one of the Ccm genes. These mouse models provide invaluable in vivo disease model to investigate molecular mechanisms and therapeutic approaches for the disease. Here, we describe detailed methodology to generate CCM disease in mouse models (Ccm1 and Ccm2-deficient) using inducible Cre/loxP recombination strategy.

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http://hdl.handle.net/10453/146973