A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.
Coignard, J
Lush, M
Beesley, J
O'Mara, TA
Dennis, J
Tyrer, JP
Barnes, DR
McGuffog, L
Leslie, G
Bolla, MK
Adank, MA
Agata, S
Ahearn, T
Aittomäki, K
Andrulis, IL
Anton-Culver, H
Arndt, V
Arnold, N
Aronson, KJ
Arun, BK
Augustinsson, A
Azzollini, J
Barrowdale, D
Baynes, C
Becher, H
Bermisheva, M
Bernstein, L
Białkowska, K
Blomqvist, C
Bojesen, SE
Bonanni, B
Borg, A
Brauch, H
Brenner, H
Burwinkel, B
Buys, SS
Caldés, T
Caligo, MA
Campa, D
Carter, BD
Castelao, JE
Chang-Claude, J
Chanock, SJ
Chung, WK
Claes, KBM
Clarke, CL
GEMO Study Collaborators,
EMBRACE Collaborators,
Collée, JM
Conroy, DM
Czene, K
Daly, MB
Devilee, P
Diez, O
Ding, YC
Domchek, SM
Dörk, T
Dos-Santos-Silva, I
Dunning, AM
Dwek, M
Eccles, DM
Eliassen, AH
Engel, C
Eriksson, M
Evans, DG
Fasching, PA
Flyger, H
Fostira, F
Friedman, E
Fritschi, L
Frost, D
Gago-Dominguez, M
Gapstur, SM
Garber, J
Garcia-Barberan, V
García-Closas, M
García-Sáenz, JA
Gaudet, MM
Gayther, SA
Gehrig, A
Georgoulias, V
Giles, GG
Godwin, AK
Goldberg, MS
Goldgar, DE
González-Neira, A
Greene, MH
Guénel, P
Haeberle, L
Hahnen, E
Haiman, CA
Håkansson, N
Hall, P
Hamann, U
Harrington, PA
Hart, SN
He, W
Hogervorst, FBL
Hollestelle, A
Hopper, JL
Horcasitas, DJ
Hulick, PJ
Hunter, DJ
Imyanitov, EN
KConFab Investigators,
HEBON Investigators,
ABCTB Investigators,
Jager, A
Jakubowska, A
James, PA
Jensen, UB
John, EM
Jones, ME
Kaaks, R
Kapoor, PM
Karlan, BY
Keeman, R
Khusnutdinova, E
Kiiski, JI
Ko, Y-D
Kosma, V-M
Kraft, P
Kurian, AW
Laitman, Y
Lambrechts, D
Le Marchand, L
Lester, J
Lesueur, F
Lindstrom, T
Lopez-Fernández, A
Loud, JT
Luccarini, C
Mannermaa, A
Manoukian, S
Margolin, S
Martens, JWM
Mebirouk, N
Meindl, A
Miller, A
Milne, RL
Montagna, M
Nathanson, KL
Neuhausen, SL
Nevanlinna, H
Nielsen, FC
O'Brien, KM
Olopade, OI
Olson, JE
Olsson, H
Osorio, A
Ottini, L
Park-Simon, T-W
Parsons, MT
Pedersen, IS
Peshkin, B
Peterlongo, P
Peto, J
Pharoah, PDP
Phillips, K-A
Polley, EC
Poppe, B
Presneau, N
Pujana, MA
Punie, K
Radice, P
Rantala, J
Rashid, MU
Rennert, G
Rennert, HS
Robson, M
Romero, A
Rossing, M
Saloustros, E
Sandler, DP
Santella, R
Scheuner, MT
Schmidt, MK
Schmidt, G
Scott, C
Sharma, P
Soucy, P
Southey, MC
Spinelli, JJ
Steinsnyder, Z
Stone, J
Stoppa-Lyonnet, D
Swerdlow, A
Tamimi, RM
Tapper, WJ
Taylor, JA
Terry, MB
Teulé, A
Thull, DL
Tischkowitz, M
Toland, AE
Torres, D
Trainer, AH
Truong, T
Tung, N
Vachon, CM
Vega, A
Vijai, J
Wang, Q
Wappenschmidt, B
Weinberg, CR
Weitzel, JN
Wendt, C
Wolk, A
Yadav, S
Yang, XR
Yannoukakos, D
Zheng, W
Ziogas, A
Zorn, KK
Park, SK
Thomassen, M
Offit, K
Schmutzler, RK
Couch, FJ
Simard, J
Chenevix-Trench, G
Easton, DF
Andrieu, N
Antoniou, AC
- Publisher:
- Springer Science and Business Media LLC
- Publication Type:
- Journal Article
- Citation:
- Nature communications, 2021, 12, (1), pp. 1078
- Issue Date:
- 2021-02-17
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Coignard, J | |
dc.contributor.author | Lush, M | |
dc.contributor.author | Beesley, J | |
dc.contributor.author | O'Mara, TA | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Tyrer, JP | |
dc.contributor.author | Barnes, DR | |
dc.contributor.author | McGuffog, L | |
dc.contributor.author | Leslie, G | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Adank, MA | |
dc.contributor.author | Agata, S | |
dc.contributor.author | Ahearn, T | |
dc.contributor.author | Aittomäki, K | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Arndt, V | |
dc.contributor.author | Arnold, N | |
dc.contributor.author | Aronson, KJ | |
dc.contributor.author | Arun, BK | |
dc.contributor.author | Augustinsson, A | |
dc.contributor.author | Azzollini, J | |
dc.contributor.author | Barrowdale, D | |
dc.contributor.author | Baynes, C | |
dc.contributor.author | Becher, H | |
dc.contributor.author | Bermisheva, M | |
dc.contributor.author | Bernstein, L | |
dc.contributor.author | Białkowska, K | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Bonanni, B | |
dc.contributor.author | Borg, A | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Buys, SS | |
dc.contributor.author | Caldés, T | |
dc.contributor.author | Caligo, MA | |
dc.contributor.author | Campa, D | |
dc.contributor.author | Carter, BD | |
dc.contributor.author | Castelao, JE | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Chung, WK | |
dc.contributor.author | Claes, KBM | |
dc.contributor.author | Clarke, CL | |
dc.contributor.author | GEMO Study Collaborators, | |
dc.contributor.author | EMBRACE Collaborators, | |
dc.contributor.author | Collée, JM | |
dc.contributor.author | Conroy, DM | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Daly, MB | |
dc.contributor.author | Devilee, P | |
dc.contributor.author | Diez, O | |
dc.contributor.author | Ding, YC | |
dc.contributor.author | Domchek, SM | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Dos-Santos-Silva, I | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Dwek, M | |
dc.contributor.author | Eccles, DM | |
dc.contributor.author | Eliassen, AH | |
dc.contributor.author | Engel, C | |
dc.contributor.author | Eriksson, M | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Flyger, H | |
dc.contributor.author | Fostira, F | |
dc.contributor.author | Friedman, E | |
dc.contributor.author | Fritschi, L | |
dc.contributor.author | Frost, D | |
dc.contributor.author | Gago-Dominguez, M | |
dc.contributor.author | Gapstur, SM | |
dc.contributor.author | Garber, J | |
dc.contributor.author | Garcia-Barberan, V | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | García-Sáenz, JA | |
dc.contributor.author | Gaudet, MM | |
dc.contributor.author | Gayther, SA | |
dc.contributor.author | Gehrig, A | |
dc.contributor.author | Georgoulias, V | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Godwin, AK | |
dc.contributor.author | Goldberg, MS | |
dc.contributor.author | Goldgar, DE | |
dc.contributor.author | González-Neira, A | |
dc.contributor.author | Greene, MH | |
dc.contributor.author | Guénel, P | |
dc.contributor.author | Haeberle, L | |
dc.contributor.author | Hahnen, E | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Håkansson, N | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Harrington, PA | |
dc.contributor.author | Hart, SN | |
dc.contributor.author | He, W | |
dc.contributor.author | Hogervorst, FBL | |
dc.contributor.author | Hollestelle, A | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Horcasitas, DJ | |
dc.contributor.author | Hulick, PJ | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | Imyanitov, EN | |
dc.contributor.author | KConFab Investigators, | |
dc.contributor.author | HEBON Investigators, | |
dc.contributor.author | ABCTB Investigators, | |
dc.contributor.author | Jager, A | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | James, PA | |
dc.contributor.author | Jensen, UB | |
dc.contributor.author | John, EM | |
dc.contributor.author | Jones, ME | |
dc.contributor.author | Kaaks, R | |
dc.contributor.author | Kapoor, PM | |
dc.contributor.author | Karlan, BY | |
dc.contributor.author | Keeman, R | |
dc.contributor.author | Khusnutdinova, E | |
dc.contributor.author | Kiiski, JI | |
dc.contributor.author | Ko, Y-D | |
dc.contributor.author | Kosma, V-M | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Kurian, AW | |
dc.contributor.author | Laitman, Y | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Lester, J | |
dc.contributor.author | Lesueur, F | |
dc.contributor.author | Lindstrom, T | |
dc.contributor.author | Lopez-Fernández, A | |
dc.contributor.author | Loud, JT | |
dc.contributor.author | Luccarini, C | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Manoukian, S | |
dc.contributor.author | Margolin, S | |
dc.contributor.author | Martens, JWM | |
dc.contributor.author | Mebirouk, N | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Miller, A | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | Montagna, M | |
dc.contributor.author | Nathanson, KL | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Nielsen, FC | |
dc.contributor.author | O'Brien, KM | |
dc.contributor.author | Olopade, OI | |
dc.contributor.author | Olson, JE | |
dc.contributor.author | Olsson, H | |
dc.contributor.author | Osorio, A | |
dc.contributor.author | Ottini, L | |
dc.contributor.author | Park-Simon, T-W | |
dc.contributor.author | Parsons, MT | |
dc.contributor.author | Pedersen, IS | |
dc.contributor.author | Peshkin, B | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Phillips, K-A | |
dc.contributor.author | Polley, EC | |
dc.contributor.author | Poppe, B | |
dc.contributor.author | Presneau, N | |
dc.contributor.author | Pujana, MA | |
dc.contributor.author | Punie, K | |
dc.contributor.author | Radice, P | |
dc.contributor.author | Rantala, J | |
dc.contributor.author | Rashid, MU | |
dc.contributor.author | Rennert, G | |
dc.contributor.author | Rennert, HS | |
dc.contributor.author | Robson, M | |
dc.contributor.author | Romero, A | |
dc.contributor.author | Rossing, M | |
dc.contributor.author | Saloustros, E | |
dc.contributor.author | Sandler, DP | |
dc.contributor.author | Santella, R | |
dc.contributor.author | Scheuner, MT | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Schmidt, G | |
dc.contributor.author | Scott, C | |
dc.contributor.author | Sharma, P | |
dc.contributor.author | Soucy, P | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Spinelli, JJ | |
dc.contributor.author | Steinsnyder, Z | |
dc.contributor.author | Stone, J | |
dc.contributor.author | Stoppa-Lyonnet, D | |
dc.contributor.author | Swerdlow, A | |
dc.contributor.author | Tamimi, RM | |
dc.contributor.author | Tapper, WJ | |
dc.contributor.author | Taylor, JA | |
dc.contributor.author | Terry, MB | |
dc.contributor.author | Teulé, A | |
dc.contributor.author | Thull, DL | |
dc.contributor.author | Tischkowitz, M | |
dc.contributor.author | Toland, AE | |
dc.contributor.author | Torres, D | |
dc.contributor.author | Trainer, AH | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Tung, N | |
dc.contributor.author | Vachon, CM | |
dc.contributor.author | Vega, A | |
dc.contributor.author | Vijai, J | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Wappenschmidt, B | |
dc.contributor.author | Weinberg, CR | |
dc.contributor.author | Weitzel, JN | |
dc.contributor.author | Wendt, C | |
dc.contributor.author | Wolk, A | |
dc.contributor.author | Yadav, S | |
dc.contributor.author | Yang, XR | |
dc.contributor.author | Yannoukakos, D | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Ziogas, A | |
dc.contributor.author | Zorn, KK | |
dc.contributor.author | Park, SK | |
dc.contributor.author | Thomassen, M | |
dc.contributor.author | Offit, K | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Andrieu, N | |
dc.contributor.author | Antoniou, AC | |
dc.date.accessioned | 2021-03-23T06:51:57Z | |
dc.date.available | 2020-11-19 | |
dc.date.available | 2021-03-23T06:51:57Z | |
dc.date.issued | 2021-02-17 | |
dc.identifier.citation | Nature communications, 2021, 12, (1), pp. 1078 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/10453/147486 | |
dc.description.abstract | Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10<sup>-8</sup>, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartof | Nature communications | |
dc.relation.isbasedon | 10.1038/s41467-020-20496-3 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in Nature communications. The final authenticated version is available online at: https://dx.doi.org/10.1038/s41467-020-20496-3. | en_US |
dc.subject.mesh | Humans | |
dc.subject.mesh | Breast Neoplasms | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | BRCA1 Protein | |
dc.subject.mesh | BRCA2 Protein | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Genotype | |
dc.subject.mesh | Linkage Disequilibrium | |
dc.subject.mesh | Mutation | |
dc.subject.mesh | Polymorphism, Single Nucleotide | |
dc.subject.mesh | Alleles | |
dc.subject.mesh | Quantitative Trait Loci | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Female | |
dc.subject.mesh | Genome-Wide Association Study | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Alleles | |
dc.subject.mesh | BRCA1 Protein | |
dc.subject.mesh | BRCA2 Protein | |
dc.subject.mesh | Breast Neoplasms | |
dc.subject.mesh | Female | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Genome-Wide Association Study | |
dc.subject.mesh | Genotype | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Linkage Disequilibrium | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Mutation | |
dc.subject.mesh | Polymorphism, Single Nucleotide | |
dc.subject.mesh | Quantitative Trait Loci | |
dc.subject.mesh | Risk Factors | |
dc.title | A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers. | |
dc.type | Journal Article | |
utslib.citation.volume | 12 | |
utslib.location.activity | England | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2021-03-23T06:51:35Z | |
pubs.issue | 1 | |
pubs.publication-status | Published | |
pubs.volume | 12 | |
utslib.citation.issue | 1 |
Abstract:
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10-8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers.
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