CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
Johnson, N
Maguire, S
Morra, A
Kapoor, PM
Tomczyk, K
Jones, ME
Schoemaker, MJ
Gilham, C
Bolla, MK
Wang, Q
Dennis, J
Floris, G
Flyger, H
Gago-Dominguez, M
Gapstur, SM
García-Closas, M
Gaudet, MM
Giles, GG
Goldberg, MS
González-Neira, A
AOCS Group,
Nordestgaard, BG
Guénel, P
Hahnen, E
Haiman, CA
Håkansson, N
Hall, P
Hamann, U
Harrington, PA
Hart, SN
Hooning, MJ
Hopper, JL
Obi, N
Howell, A
Hunter, DJ
ABCTB Investigators,
kConFab Investigators,
Jager, A
Jakubowska, A
John, EM
Kaaks, R
Keeman, R
Khusnutdinova, E
Olshan, AF
Kitahara, CM
Kosma, V-M
Koutros, S
Kraft, P
Kristensen, VN
Kurian, AW
Lambrechts, D
Le Marchand, L
Linet, M
Lubiński, J
Olson, JE
Mannermaa, A
Manoukian, S
Margolin, S
Martens, JWM
Mavroudis, D
Mayes, R
Meindl, A
Milne, RL
Neuhausen, SL
Nevanlinna, H
Olsson, H
Newman, WG
Nielsen, SF
Orban, E
Park-Simon, T-W
Peterlongo, P
Plaseska-Karanfilska, D
Pylkäs, K
Ahearn, TU
Rennert, G
Rennert, HS
Ruddy, KJ
Saloustros, E
Sandler, DP
Sawyer, EJ
Schmutzler, RK
Scott, C
Shu, X-O
Simard, J
Andrulis, IL
Smichkoska, S
Sohn, C
Southey, MC
Spinelli, JJ
Stone, J
Tamimi, RM
Taylor, JA
Tollenaar, RAEM
Tomlinson, I
Troester, MA
Anton-Culver, H
Truong, T
Vachon, CM
van Veen, EM
Wang, SS
Weinberg, CR
Wendt, C
Wildiers, H
Winqvist, R
Wolk, A
Zheng, W
Antonenkova, NN
Ziogas, A
Dunning, AM
Pharoah, PDP
Easton, DF
Howie, AF
Peto, J
Dos-Santos-Silva, I
Swerdlow, AJ
Chang-Claude, J
Schmidt, MK
Arndt, V
Orr, N
Fletcher, O
Aronson, KJ
Augustinsson, A
Baynes, C
Freeman, LEB
Beckmann, MW
Benitez, J
Bermisheva, M
Blomqvist, C
Boeckx, B
Bogdanova, NV
Bojesen, SE
Brauch, H
Brenner, H
Burwinkel, B
Campa, D
Canzian, F
Castelao, JE
Chanock, SJ
Chenevix-Trench, G
Clarke, CL
NBCS Collaborators,
Conroy, DM
Couch, FJ
Cox, A
Cross, SS
Czene, K
Dörk, T
Eliassen, AH
Engel, C
Evans, DG
Fasching, PA
Figueroa, J
- Publisher:
- Springer Science and Business Media LLC
- Publication Type:
- Journal Article
- Citation:
- British journal of cancer, 2021, 124, (4), pp. 842-854
- Issue Date:
- 2021-02
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Johnson, N | |
dc.contributor.author | Maguire, S | |
dc.contributor.author | Morra, A | |
dc.contributor.author | Kapoor, PM | |
dc.contributor.author | Tomczyk, K | |
dc.contributor.author | Jones, ME | |
dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Gilham, C | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Floris, G | |
dc.contributor.author | Flyger, H | |
dc.contributor.author | Gago-Dominguez, M | |
dc.contributor.author | Gapstur, SM | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | Gaudet, MM | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Goldberg, MS | |
dc.contributor.author | González-Neira, A | |
dc.contributor.author | AOCS Group, | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | Guénel, P | |
dc.contributor.author | Hahnen, E | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Håkansson, N | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Harrington, PA | |
dc.contributor.author | Hart, SN | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Obi, N | |
dc.contributor.author | Howell, A | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | ABCTB Investigators, | |
dc.contributor.author | kConFab Investigators, | |
dc.contributor.author | Jager, A | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | John, EM | |
dc.contributor.author | Kaaks, R | |
dc.contributor.author | Keeman, R | |
dc.contributor.author | Khusnutdinova, E | |
dc.contributor.author | Olshan, AF | |
dc.contributor.author | Kitahara, CM | |
dc.contributor.author | Kosma, V-M | |
dc.contributor.author | Koutros, S | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Kristensen, VN | |
dc.contributor.author | Kurian, AW | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Linet, M | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Olson, JE | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Manoukian, S | |
dc.contributor.author | Margolin, S | |
dc.contributor.author | Martens, JWM | |
dc.contributor.author | Mavroudis, D | |
dc.contributor.author | Mayes, R | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Olsson, H | |
dc.contributor.author | Newman, WG | |
dc.contributor.author | Nielsen, SF | |
dc.contributor.author | Orban, E | |
dc.contributor.author | Park-Simon, T-W | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Plaseska-Karanfilska, D | |
dc.contributor.author | Pylkäs, K | |
dc.contributor.author | Ahearn, TU | |
dc.contributor.author | Rennert, G | |
dc.contributor.author | Rennert, HS | |
dc.contributor.author | Ruddy, KJ | |
dc.contributor.author | Saloustros, E | |
dc.contributor.author | Sandler, DP | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Scott, C | |
dc.contributor.author | Shu, X-O | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Smichkoska, S | |
dc.contributor.author | Sohn, C | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Spinelli, JJ | |
dc.contributor.author | Stone, J | |
dc.contributor.author | Tamimi, RM | |
dc.contributor.author | Taylor, JA | |
dc.contributor.author | Tollenaar, RAEM | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Troester, MA | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Vachon, CM | |
dc.contributor.author | van Veen, EM | |
dc.contributor.author | Wang, SS | |
dc.contributor.author | Weinberg, CR | |
dc.contributor.author | Wendt, C | |
dc.contributor.author | Wildiers, H | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Wolk, A | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Antonenkova, NN | |
dc.contributor.author | Ziogas, A | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Howie, AF | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Dos-Santos-Silva, I | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Arndt, V | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Fletcher, O | |
dc.contributor.author | Aronson, KJ | |
dc.contributor.author | Augustinsson, A | |
dc.contributor.author | Baynes, C | |
dc.contributor.author | Freeman, LEB | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Bermisheva, M | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Boeckx, B | |
dc.contributor.author | Bogdanova, NV | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Campa, D | |
dc.contributor.author | Canzian, F | |
dc.contributor.author | Castelao, JE | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Clarke, CL | |
dc.contributor.author | NBCS Collaborators, | |
dc.contributor.author | Conroy, DM | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Cox, A | |
dc.contributor.author | Cross, SS | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Eliassen, AH | |
dc.contributor.author | Engel, C | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Figueroa, J | |
dc.date.accessioned | 2021-03-23T06:54:12Z | |
dc.date.available | 2020-11-05 | |
dc.date.available | 2021-03-23T06:54:12Z | |
dc.date.issued | 2021-02 | |
dc.identifier.citation | British journal of cancer, 2021, 124, (4), pp. 842-854 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.issn | 1532-1827 | |
dc.identifier.uri | http://hdl.handle.net/10453/147487 | |
dc.description.abstract | <h4>Background</h4>Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk.<h4>Methods</h4>We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry.<h4>Results</h4>For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (-49.2%, 95% CI -56.1% to -41.1%, P = 3.1 × 10<sup>-18</sup>); in follow-up analyses, rs45446698-C was also associated with lower progesterone (-26.7%, 95% CI -39.4% to -11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82-0.91, P = 6.9 × 10<sup>-8</sup>).<h4>Conclusions</h4>The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartof | British journal of cancer | |
dc.relation.isbasedon | 10.1038/s41416-020-01185-w | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Open AccessThis article is licensed under a Creative CommonsAttribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the CreativeCommons license, and indicate if changes were made. The images or other third partymaterial in this article are included in the article’s Creative Commons license, unlessindicated otherwise in a credit line to the material. If material is not included in thearticle’s Creative Commons license and your intended use is not permitted by statutoryregulation or exceeds the permitted use, you will need to obtain permission directlyfrom the copyright holder. To view a copy of this license, visithttp://creativecommons.org/licenses/by/4.0/. | |
dc.subject | 1112 Oncology and Carcinogenesis, 1117 Public Health and Health Services | |
dc.subject.classification | Oncology & Carcinogenesis | |
dc.title | CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. | |
dc.type | Journal Article | |
utslib.citation.volume | 124 | |
utslib.location.activity | England | |
utslib.for | 1112 Oncology and Carcinogenesis | |
utslib.for | 1117 Public Health and Health Services | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2021-03-23T06:54:02Z | |
pubs.issue | 4 | |
pubs.publication-status | Published | |
pubs.volume | 124 | |
utslib.citation.issue | 4 |
Abstract:
Background
Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk.Methods
We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry.Results
For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (-49.2%, 95% CI -56.1% to -41.1%, P = 3.1 × 10-18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (-26.7%, 95% CI -39.4% to -11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82-0.91, P = 6.9 × 10-8).Conclusions
The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.Please use this identifier to cite or link to this item:
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