Evidence for inactivation of cysteine proteases by reactive carbonyls via glycation of active site thiols

Portland Press Ltd
Publication Type:
Journal Article
Biochemical Journal, 2006, 398 (2), pp. 197 - 206
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Hyperglycaemia, triose phosphate decomposition and oxidation reactions generate reactive aldehydes in vivo. These compounds react non-enzymatically with protein side chains and N-terminal amino groups to give adducts and cross-links, and hence modified p
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