Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response

Wiley-Blackwell Publishing Ltd.
Publication Type:
Journal Article
FEMS Yeast Research, 2007, 7 (8), pp. 1230 - 1236
Issue Date:
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2010001947OK.pdf458.23 kB
Adobe PDF
The 42 amino acid Alzheimer's A beta peptide is involved in the progression of Alzheimer's disease. Here we describe the effects of intracellular A beta, produced through its attachment to either end of a green fluorescent protein, in yeast. Cells producing A beta exhibited a lower growth yield and a heat shock response, showing that A beta fusions promote stress in cells and supporting the notion that intracellular A beta is a toxic molecule. These studies have relevance in understanding the role of A beta in the death of neuronal cells, and indicate that yeast may be a new tractable model system for the screening for inhibitors of the stress caused by A beta.
Please use this identifier to cite or link to this item: