Alzheimer's Abeta fused to green fluorescent protein induces growth stress and a heat shock response

Publisher:
Wiley-Blackwell Publishing Ltd.
Publication Type:
Journal Article
Citation:
FEMS Yeast Research, 2007, 7 (8), pp. 1230 - 1236
Issue Date:
2007-01
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The 42 amino acid Alzheimer's A beta peptide is involved in the progression of Alzheimer's disease. Here we describe the effects of intracellular A beta, produced through its attachment to either end of a green fluorescent protein, in yeast. Cells producing A beta exhibited a lower growth yield and a heat shock response, showing that A beta fusions promote stress in cells and supporting the notion that intracellular A beta is a toxic molecule. These studies have relevance in understanding the role of A beta in the death of neuronal cells, and indicate that yeast may be a new tractable model system for the screening for inhibitors of the stress caused by A beta.
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