Coated glass capillaries as SPME devices for DART mass spectrometry.

Cody, R; Maleknia, SD

Coated glass capillaries as SPME devices for DART mass spectrometry.

Cody, R Maleknia, SD

Permalink

Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Rapid communications in mass spectrometry : RCM, 2020, 34, (23)
Issue Date:: 2020-12

Closed Access

	Filename	Description	Size
	rcm.8946.pdf		9.36 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Cody, R
dc.contributor.author	Maleknia, SD
dc.date.accessioned	2021-05-25T07:30:30Z
dc.date.available	2020-09-07
dc.date.available	2021-05-25T07:30:30Z
dc.date.issued	2020-12
dc.identifier.citation	Rapid communications in mass spectrometry : RCM, 2020, 34, (23)
dc.identifier.issn	0951-4198
dc.identifier.issn	1097-0231
dc.identifier.uri	http://hdl.handle.net/10453/149211
dc.description.abstract	<h4>Rationale</h4>Solid-phase microextraction (SPME) provides high-throughput sample cleanup and pre-concentration. Here we demonstrate coated glass capillaries (CGCs) as SPME devices for specific applications in direct analysis in real time (DART) mass spectrometry, referred to as "CGC-DART", for rapid screening of environmental contaminants at low parts-per-trillion detection limits and with accurate identification of analytes.<h4>Methods</h4>The extraction is performed in a one-step process in minutes by dipping the CGC in solutions containing the analytes, and then placing the CGC in a DART source for analysis. CGCs are disposable and relatively inexpensive in comparison with SPME devices, and can be prepared with hydrophobic, hydrophilic or mixed-mode materials similar to SPME. CGCs were prepared by adsorption coating with incubation of capillaries in saturated solutions of octadecylamine or covalent activation of silanes.<h4>Results</h4>Quantitation is shown with perfluorooctanoic acid (PFOA) at 1 ppt to 100 ppb, with the lowest detection at 500 parts-per quadrillion (ppq) in tap water. One-step extraction of contaminated groundwater from Northern Queensland, Australia, revealed perfluorooctane sulfonate (PFOS) and perfluorohexanesulfonamide as well as C4-C8 perfluoroalkyl carboxylic acids. A soil sample taken near a former military air base (New Hampshire, USA) revealed the presence of perfluorononanoic acid (PFNA) at 1 ppb and traces of perfluoroheptanoic acid.<h4>Conclusions</h4>CGC-DART enabled one-step extraction of PFASs in minutes with mL sample volumes at low concentrations as shown for the standards and contaminated soil and water samples. DART-MS combined with Kendrick mass defect analysis enabled accurate identification of PFASs without chromatography steps, as fluorinated compounds are mass deficient and easily distinguished over background signal.
dc.format	Print
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	Rapid communications in mass spectrometry : RCM
dc.relation.isbasedon	10.1002/rcm.8946
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	03 Chemical Sciences, 04 Earth Sciences, 06 Biological Sciences
dc.subject.classification	Analytical Chemistry
dc.title	Coated glass capillaries as SPME devices for DART mass spectrometry.
dc.type	Journal Article
utslib.citation.volume	34
utslib.location.activity	England
utslib.for	03 Chemical Sciences
utslib.for	04 Earth Sciences
utslib.for	06 Biological Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-05-25T07:30:24Z
pubs.issue	23
pubs.publication-status	Published
pubs.volume	34
utslib.citation.issue	23

Abstract:

Rationale

Solid-phase microextraction (SPME) provides high-throughput sample cleanup and pre-concentration. Here we demonstrate coated glass capillaries (CGCs) as SPME devices for specific applications in direct analysis in real time (DART) mass spectrometry, referred to as "CGC-DART", for rapid screening of environmental contaminants at low parts-per-trillion detection limits and with accurate identification of analytes.

Methods

The extraction is performed in a one-step process in minutes by dipping the CGC in solutions containing the analytes, and then placing the CGC in a DART source for analysis. CGCs are disposable and relatively inexpensive in comparison with SPME devices, and can be prepared with hydrophobic, hydrophilic or mixed-mode materials similar to SPME. CGCs were prepared by adsorption coating with incubation of capillaries in saturated solutions of octadecylamine or covalent activation of silanes.

Results

Quantitation is shown with perfluorooctanoic acid (PFOA) at 1 ppt to 100 ppb, with the lowest detection at 500 parts-per quadrillion (ppq) in tap water. One-step extraction of contaminated groundwater from Northern Queensland, Australia, revealed perfluorooctane sulfonate (PFOS) and perfluorohexanesulfonamide as well as C4-C8 perfluoroalkyl carboxylic acids. A soil sample taken near a former military air base (New Hampshire, USA) revealed the presence of perfluorononanoic acid (PFNA) at 1 ppb and traces of perfluoroheptanoic acid.

Conclusions

CGC-DART enabled one-step extraction of PFASs in minutes with mL sample volumes at low concentrations as shown for the standards and contaminated soil and water samples. DART-MS combined with Kendrick mass defect analysis enabled accurate identification of PFASs without chromatography steps, as fluorinated compounds are mass deficient and easily distinguished over background signal.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/149211