Astroglial Connexins in Neurodegenerative Diseases

Huang, X; Su, Y; Wang, N; Li, H; Li, Z; Yin, G; Chen, H; Niu, J; Yi, C

Astroglial Connexins in Neurodegenerative Diseases

Huang, X Su, Y Wang, N Li, H Li, Z Yin, G Chen, H

Niu, J Yi, C

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Publisher:: Frontiers Media SA
Publication Type:: Journal Article
Citation:: Frontiers in Molecular Neuroscience, 14

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Field	Value	Language
dc.contributor.author	Huang, X
dc.contributor.author	Su, Y
dc.contributor.author	Wang, N
dc.contributor.author	Li, H
dc.contributor.author	Li, Z
dc.contributor.author	Yin, G
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752
dc.contributor.author	Niu, J
dc.contributor.author	Yi, C
dc.date.accessioned	2021-05-31T03:39:46Z
dc.date.available	2021-05-31T03:39:46Z
dc.identifier.citation	Frontiers in Molecular Neuroscience, 14
dc.identifier.issn	1662-5099
dc.identifier.uri	http://hdl.handle.net/10453/149309
dc.description.abstract	<jats:p>Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive astrogliosis, in response to the insults to the CNS. One of the key aspects of the reactive astrocytes is the change in the expression and function of connexins. Connexins are channel proteins that highly expressed in astrocytes, forming gap junction channels and hemichannels, allowing diffusional trafficking of small molecules. Alterations of astrocytic connexin expression and function found in neurodegenerative diseases have been shown to affect the disease progression by changing neuronal function and survival. In this review, we will summarize the role of astroglial connexins in neurodegenerative diseases including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Also, we will discuss why targeting connexins can be a plausible therapeutic strategy to manage these neurodegenerative diseases.</jats:p>
dc.language	en
dc.publisher	Frontiers Media SA
dc.relation.ispartof	Frontiers in Molecular Neuroscience
dc.relation.isbasedon	10.3389/fnmol.2021.657514
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1109 Neurosciences
dc.title	Astroglial Connexins in Neurodegenerative Diseases
dc.type	Journal Article
utslib.citation.volume	14
utslib.for	1103 Clinical Sciences
utslib.for	1109 Neurosciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2021-05-31T03:39:45Z
pubs.publication-status	Published online
pubs.volume	14

Abstract:

Astrocytes play a crucial role in the maintenance of the normal functions of the Central Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, a process called reactive astrogliosis, in response to the insults to the CNS. One of the key aspects of the reactive astrocytes is the change in the expression and function of connexins. Connexins are channel proteins that highly expressed in astrocytes, forming gap junction channels and hemichannels, allowing diffusional trafficking of small molecules. Alterations of astrocytic connexin expression and function found in neurodegenerative diseases have been shown to affect the disease progression by changing neuronal function and survival. In this review, we will summarize the role of astroglial connexins in neurodegenerative diseases including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Also, we will discuss why targeting connexins can be a plausible therapeutic strategy to manage these neurodegenerative diseases.

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http://hdl.handle.net/10453/149309