Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions in Strains from Nigeria, Sudan, and South Sudan.

Prosser, C; Gresty, K; Ellis, J; Meyer, W; Anderson, K; Lee, R; Cheng, Q

Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions in Strains from Nigeria, Sudan, and South Sudan.

Prosser, C Gresty, K Ellis, J

Meyer, W Anderson, K Lee, R Cheng, Q

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Publisher:: CENTERS DISEASE CONTROL & PREVENTION
Publication Type:: Journal Article
Citation:: Emerging infectious diseases, 2021, 27, (2), pp. 471-479
Issue Date:: 2021-02

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Field	Value	Language
dc.contributor.author	Prosser, C
dc.contributor.author	Gresty, K
dc.contributor.author	Ellis, J https://orcid.org/0000-0001-7328-4831
dc.contributor.author	Meyer, W
dc.contributor.author	Anderson, K
dc.contributor.author	Lee, R
dc.contributor.author	Cheng, Q
dc.date.accessioned	2021-06-04T01:56:05Z
dc.date.available	2021-06-04T01:56:05Z
dc.date.issued	2021-02
dc.identifier.citation	Emerging infectious diseases, 2021, 27, (2), pp. 471-479
dc.identifier.issn	1080-6040
dc.identifier.issn	1080-6059
dc.identifier.uri	http://hdl.handle.net/10453/149409
dc.description.abstract	Deletion of histidine-rich protein genes pfhrp2/3 in Plasmodium falciparum causes infections to go undetected by HRP2-based malaria rapid diagnostic tests. We analyzed P. falciparum malaria cases imported to Australia (n = 210, collected 2010-2018) for their pfhrp2/3 status. We detected gene deletions in patients from 12 of 25 countries. We found >10% pfhrp2-deletion levels in those from Nigeria (13.3%, n = 30), Sudan (11.2%, n = 39), and South Sudan (17.7%, n = 17) and low levels of pfhrp3 deletion from Sudan (3.6%) and South Sudan (5.9%). No parasites with pfhrp2/3 double deletions were detected. Microsatellite typing of parasites from Nigeria, Sudan, and South Sudan revealed low relatedness among gene-deleted parasites, indicating independent emergences. The gene deletion proportions signify a risk of false-negative HRP2-RDT results. This study's findings warrant surveillance to determine whether the prevalence of gene-deleted parasites justifies switching malaria rapid diagnostic tests in Nigeria, Sudan, and South Sudan.
dc.format	Print
dc.language	eng
dc.publisher	CENTERS DISEASE CONTROL & PREVENTION
dc.relation.ispartof	Emerging infectious diseases
dc.relation.isbasedon	10.3201/eid2702.191410
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1108 Medical Microbiology, 1117 Public Health and Health Services
dc.subject.classification	Microbiology
dc.title	Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions in Strains from Nigeria, Sudan, and South Sudan.
dc.type	Journal Article
utslib.citation.volume	27
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1108 Medical Microbiology
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2021-06-04T01:56:03Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	27
utslib.citation.issue	2

Abstract:

Deletion of histidine-rich protein genes pfhrp2/3 in Plasmodium falciparum causes infections to go undetected by HRP2-based malaria rapid diagnostic tests. We analyzed P. falciparum malaria cases imported to Australia (n = 210, collected 2010-2018) for their pfhrp2/3 status. We detected gene deletions in patients from 12 of 25 countries. We found >10% pfhrp2-deletion levels in those from Nigeria (13.3%, n = 30), Sudan (11.2%, n = 39), and South Sudan (17.7%, n = 17) and low levels of pfhrp3 deletion from Sudan (3.6%) and South Sudan (5.9%). No parasites with pfhrp2/3 double deletions were detected. Microsatellite typing of parasites from Nigeria, Sudan, and South Sudan revealed low relatedness among gene-deleted parasites, indicating independent emergences. The gene deletion proportions signify a risk of false-negative HRP2-RDT results. This study's findings warrant surveillance to determine whether the prevalence of gene-deleted parasites justifies switching malaria rapid diagnostic tests in Nigeria, Sudan, and South Sudan.

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http://hdl.handle.net/10453/149409