Growth inhibition of Candida species and Aspergillus fumigatus by statins

Macreadie, IG; Johnson, G; Schlosser, T; Macreadie, PI

Growth inhibition of Candida species and Aspergillus fumigatus by statins

Macreadie, IG Johnson, G Schlosser, T Macreadie, PI

Permalink

Publication Type:: Journal Article
Citation:: FEMS Microbiology Letters, 2006, 262 (1), pp. 9 - 13
Issue Date:: 2006-09-01

Closed Access

	Filename	Description	Size
	2010001967OK.pdf		180.39 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Macreadie, IG	en_US
dc.contributor.author	Johnson, G	en_US
dc.contributor.author	Schlosser, T	en_US
dc.contributor.author	Macreadie, PI https://orcid.org/0000-0001-7362-0882	en_US
dc.date.issued	2006-09-01	en_US
dc.identifier.citation	FEMS Microbiology Letters, 2006, 262 (1), pp. 9 - 13	en_US
dc.identifier.issn	0378-1097	en_US
dc.identifier.uri	http://hdl.handle.net/10453/14961
dc.description.abstract	Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins, simvastatin and atorvastatin, on five Candida species and Aspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A. fumigatus with ergosterol or cholesterol in aerobic culture led to substantial recovery from the inhibition by statins, suggesting specificity of statins for the mevalonate synthesis pathway. Our findings suggest that the statins could have utility as antifungal agents and that fungal colonization could be affected in those on statin therapy. © 2006 CSIRO.	en_US
dc.relation.ispartof	FEMS Microbiology Letters	en_US
dc.relation.isbasedon	10.1111/j.1574-6968.2006.00370.x	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Aspergillus fumigatus	en_US
dc.subject.mesh	Candida	en_US
dc.subject.mesh	Mevalonic Acid	en_US
dc.subject.mesh	Pyrroles	en_US
dc.subject.mesh	Simvastatin	en_US
dc.subject.mesh	Cholesterol	en_US
dc.subject.mesh	Ergosterol	en_US
dc.subject.mesh	Heptanoic Acids	en_US
dc.subject.mesh	Growth Inhibitors	en_US
dc.subject.mesh	Hydroxymethylglutaryl-CoA Reductase Inhibitors	en_US
dc.subject.mesh	Antifungal Agents	en_US
dc.subject.mesh	Atorvastatin	en_US
dc.title	Growth inhibition of Candida species and Aspergillus fumigatus by statins	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	262	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	07 Agricultural and Veterinary Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	262	en_US

Abstract:

Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins, simvastatin and atorvastatin, on five Candida species and Aspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A. fumigatus with ergosterol or cholesterol in aerobic culture led to substantial recovery from the inhibition by statins, suggesting specificity of statins for the mevalonate synthesis pathway. Our findings suggest that the statins could have utility as antifungal agents and that fungal colonization could be affected in those on statin therapy. © 2006 CSIRO.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/14961