Topological Optimization of Auxetic Coronary Stents Considering Hemodynamics

Xue, H; Saha, SC; Beier, S; Jepson, N; Luo, Z

Topological Optimization of Auxetic Coronary Stents Considering Hemodynamics

Xue, H Saha, SC Beier, S Jepson, N Luo, Z

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Publisher:: Frontiers Media SA
Publication Type:: Journal Article
Citation:: Frontiers in Bioengineering and Biotechnology, 9

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Field	Value	Language
dc.contributor.author	Xue, H
dc.contributor.author	Saha, SC
dc.contributor.author	Beier, S
dc.contributor.author	Jepson, N
dc.contributor.author	Luo, Z https://orcid.org/0000-0002-6953-3986
dc.date.accessioned	2021-09-18T13:44:58Z
dc.date.available	2021-09-18T13:44:58Z
dc.identifier.citation	Frontiers in Bioengineering and Biotechnology, 9
dc.identifier.issn	2296-4185
dc.identifier.uri	http://hdl.handle.net/10453/150633
dc.description.abstract	<jats:p>This paper is to design a new type of auxetic metamaterial-inspired structural architectures to innovate coronary stents under hemodynamics via a topological optimization method. The new architectures will low the occurrence of stent thrombosis (ST) and in-stent restenosis (ISR) associated with the mechanical factors and the adverse hemodynamics. A multiscale level-set approach with the numerical homogenization method and computational fluid dynamics is applied to implement auxetic microarchitectures and stenting structure. A homogenized effective modified fluid permeability (MFP) is proposed to efficiently connect design variables with motions of blood flow around the stent, and a Darcy-Stokes system is used to describe the coupling behavior of the stent structure and fluid. The optimization is formulated to include three objectives from different scales: MFP and auxetic property in the microscale and stenting stiffness in the macroscale. The design is numerically validated in the commercial software MATLAB and ANSYS, respectively. The simulation results show that the new design can not only supply desired auxetic behavior to benefit the deliverability and reduce incidence of the mechanical failure but also improve wall shear stress distribution to low the induced adverse hemodynamic changes. Hence, the proposed stenting architectures can help improve safety in stent implantation, to facilitate design of new generation of stents.</jats:p>
dc.language	en
dc.publisher	Frontiers Media SA
dc.relation	http://purl.org/au-research/grants/arc/DP210101353
dc.relation.ispartof	Frontiers in Bioengineering and Biotechnology
dc.relation.isbasedon	10.3389/fbioe.2021.728914
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0699 Other Biological Sciences, 0903 Biomedical Engineering, 1004 Medical Biotechnology
dc.title	Topological Optimization of Auxetic Coronary Stents Considering Hemodynamics
dc.type	Journal Article
utslib.citation.volume	9
utslib.for	0699 Other Biological Sciences
utslib.for	0903 Biomedical Engineering
utslib.for	1004 Medical Biotechnology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2021-09-18T13:44:52Z
pubs.publication-status	Published online
pubs.volume	9

Abstract:

This paper is to design a new type of auxetic metamaterial-inspired structural architectures to innovate coronary stents under hemodynamics via a topological optimization method. The new architectures will low the occurrence of stent thrombosis (ST) and in-stent restenosis (ISR) associated with the mechanical factors and the adverse hemodynamics. A multiscale level-set approach with the numerical homogenization method and computational fluid dynamics is applied to implement auxetic microarchitectures and stenting structure. A homogenized effective modified fluid permeability (MFP) is proposed to efficiently connect design variables with motions of blood flow around the stent, and a Darcy-Stokes system is used to describe the coupling behavior of the stent structure and fluid. The optimization is formulated to include three objectives from different scales: MFP and auxetic property in the microscale and stenting stiffness in the macroscale. The design is numerically validated in the commercial software MATLAB and ANSYS, respectively. The simulation results show that the new design can not only supply desired auxetic behavior to benefit the deliverability and reduce incidence of the mechanical failure but also improve wall shear stress distribution to low the induced adverse hemodynamic changes. Hence, the proposed stenting architectures can help improve safety in stent implantation, to facilitate design of new generation of stents.

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http://hdl.handle.net/10453/150633