Cinnamon as Dietary Supplement Caused Hyperlipidemia in Healthy Rats

Huang, X; Cai, H; Li, H; Su, Y; Li, H; Li, W; Yi, C; Oliver, BG; Chen, H

Cinnamon as Dietary Supplement Caused Hyperlipidemia in Healthy Rats

Huang, X Cai, H Li, H Su, Y Li, H Li, W Yi, C Oliver, BG Chen, H

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Publisher:: HINDAWI LTD
Publication Type:: Journal Article
Citation:: Evidence-based Complementary and Alternative Medicine, 2021, 2021, pp. 9892088
Issue Date:: 2021-07-02

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Field	Value	Language
dc.contributor.author	Huang, X
dc.contributor.author	Cai, H
dc.contributor.author	Li, H
dc.contributor.author	Su, Y
dc.contributor.author	Li, H
dc.contributor.author	Li, W
dc.contributor.author	Yi, C
dc.contributor.author	Oliver, BG
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752
dc.date.accessioned	2021-10-28T06:37:16Z
dc.date.available	2021-06-26
dc.date.available	2021-10-28T06:37:16Z
dc.date.issued	2021-07-02
dc.identifier.citation	Evidence-based Complementary and Alternative Medicine, 2021, 2021, pp. 9892088
dc.identifier.issn	1741-427X
dc.identifier.issn	1741-4288
dc.identifier.uri	http://hdl.handle.net/10453/151252
dc.description.abstract	<h4>Objective</h4>Cinnamon is a cooking spice and a medicinal herb. It is increasingly used as a health supplement due to its perceived benefit to prevent and or manage type 2 diabetes and metabolic disorders. However, it is unclear if regular consumption of this medicinal plant will interfere with normal physiological functions. Therefore, this study investigated the impact of daily cinnamon supplements on glucose and lipid metabolic profiles in healthy rats.<h4>Methods</h4>Male rats (Sprague Dawley, 8 weeks) were supplied with cinnamon in their diet (equivalent to ∼1 g/day in humans) for two weeks. Blood glucose and lipid levels, as well as metabolic markers in both liver and abdominal white adipose tissue, were measured.<h4>Results</h4>Cinnamon significantly increased fat mass and blood cholesterol and low-density lipoprotein (LDL) levels, but reduced fasting blood glucose level by 12%. Liver functional enzymes were normal in rats consuming cinnamon. However, several lipid metabolic markers were impaired which may contribute to dyslipidemia, including two main switches for energy metabolism (sirtuin 1 and peroxisome proliferator-activated receptor-gamma coactivator-1<i>α</i>) and the LDL receptor. However, <i>de novo</i> lipid synthesis enzymes and inflammatory markers were also reduced in the liver by cinnamon treatment, which may potentially prevent the development of steatosis. Markers for lipid oxidation were downregulated in fat tissue in cinnamon-treated rats, contributing to increased fat accumulation.<h4>Conclusion</h4>Daily low-dose cinnamon supplementation seems to promote abdominal adipose tissue accumulation and disturb lipid homeostasis in healthy rats, raising the concerns regarding daily use in healthy people.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	HINDAWI LTD
dc.relation.ispartof	Evidence-based Complementary and Alternative Medicine
dc.relation.isbasedon	10.1155/2021/9892088
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1104 Complementary and Alternative Medicine
dc.subject.classification	Complementary & Alternative Medicine
dc.title	Cinnamon as Dietary Supplement Caused Hyperlipidemia in Healthy Rats
dc.type	Journal Article
utslib.citation.volume	2021
utslib.location.activity	United States
utslib.for	1104 Complementary and Alternative Medicine
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2021-10-28T06:37:13Z
pubs.publication-status	Published
pubs.volume	2021

Abstract:

Objective

Cinnamon is a cooking spice and a medicinal herb. It is increasingly used as a health supplement due to its perceived benefit to prevent and or manage type 2 diabetes and metabolic disorders. However, it is unclear if regular consumption of this medicinal plant will interfere with normal physiological functions. Therefore, this study investigated the impact of daily cinnamon supplements on glucose and lipid metabolic profiles in healthy rats.

Methods

Male rats (Sprague Dawley, 8 weeks) were supplied with cinnamon in their diet (equivalent to ∼1 g/day in humans) for two weeks. Blood glucose and lipid levels, as well as metabolic markers in both liver and abdominal white adipose tissue, were measured.

Results

Cinnamon significantly increased fat mass and blood cholesterol and low-density lipoprotein (LDL) levels, but reduced fasting blood glucose level by 12%. Liver functional enzymes were normal in rats consuming cinnamon. However, several lipid metabolic markers were impaired which may contribute to dyslipidemia, including two main switches for energy metabolism (sirtuin 1 and peroxisome proliferator-activated receptor-gamma coactivator-1α) and the LDL receptor. However, de novo lipid synthesis enzymes and inflammatory markers were also reduced in the liver by cinnamon treatment, which may potentially prevent the development of steatosis. Markers for lipid oxidation were downregulated in fat tissue in cinnamon-treated rats, contributing to increased fat accumulation.

Conclusion

Daily low-dose cinnamon supplementation seems to promote abdominal adipose tissue accumulation and disturb lipid homeostasis in healthy rats, raising the concerns regarding daily use in healthy people.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/151252