Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients

Castrogiovanni, P; Sanfilippo, C; Imbesi, R; Maugeri, G; Lo Furno, D; Tibullo, D; Castorina, A; Musumeci, G; Di Rosa, M

Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients

Castrogiovanni, P Sanfilippo, C Imbesi, R Maugeri, G Lo Furno, D Tibullo, D Castorina, A

Musumeci, G Di Rosa, M

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Cells, 2021, 10, (4)
Issue Date:: 2021-04-13

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Field	Value	Language
dc.contributor.author	Castrogiovanni, P
dc.contributor.author	Sanfilippo, C
dc.contributor.author	Imbesi, R
dc.contributor.author	Maugeri, G
dc.contributor.author	Lo Furno, D
dc.contributor.author	Tibullo, D
dc.contributor.author	Castorina, A https://orcid.org/0000-0001-7037-759X
dc.contributor.author	Musumeci, G
dc.contributor.author	Di Rosa, M
dc.date.accessioned	2021-12-01T09:50:21Z
dc.date.available	2021-04-12
dc.date.available	2021-12-01T09:50:21Z
dc.date.issued	2021-04-13
dc.identifier.citation	Cells, 2021, 10, (4)
dc.identifier.issn	2073-4409
dc.identifier.issn	2073-4409
dc.identifier.uri	http://hdl.handle.net/10453/151999
dc.description.abstract	Alzheimer's disease is a progressive, devastating, and irreversible brain disorder that, day by day, destroys memory skills and social behavior. Despite this, the number of known genes suitable for discriminating between AD patients is insufficient. Among the genes potentially involved in the development of AD, there are the chitinase-like proteins (CLPs) CHI3L1, CHI3L2, and CHID1. The genes of the first two have been extensively investigated while, on the contrary, little information is available on CHID1. In this manuscript, we conducted transcriptome meta-analysis on an extensive sample of brains of healthy control subjects (n = 1849) (NDHC) and brains of AD patients (n = 1170) in order to demonstrate CHID1 involvement. Our analysis revealed an inverse correlation between the brain <i>CHID1</i> expression levels and the age of NDHC subjects. Significant differences were highlighted comparing CHID1 expression of NDHC subjects and AD patients. Exclusive in AD patients, the <i>CHID1</i> expression levels were correlated positively to calcium-binding adapter molecule 1 (<i>IBA1</i>) levels. Furthermore, both in NDHC and in AD patient's brains, the <i>CHID1</i> expression levels were directly correlated with calbindin 1 (<i>CALB1</i>) and neurogranin (<i>NRGN</i>). According to brain regions, correlation differences were shown between the expression levels of <i>CHID1</i> in prefrontal, frontal, occipital, cerebellum, temporal, and limbic system. Sex-related differences were only highlighted in NDHC. CHID1 represents a new chitinase potentially involved in the principal processes underlying Alzheimer's disease.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Cells
dc.relation.isbasedon	10.3390/cells10040882
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Alzheimer Disease
dc.subject.mesh	Brain
dc.subject.mesh	Brain Mapping
dc.subject.mesh	Calbindin 1
dc.subject.mesh	Calcium-Binding Proteins
dc.subject.mesh	Carrier Proteins
dc.subject.mesh	Case-Control Studies
dc.subject.mesh	Computational Biology
dc.subject.mesh	Female
dc.subject.mesh	Gene Expression Profiling
dc.subject.mesh	Gene Expression Regulation
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Microfilament Proteins
dc.subject.mesh	Middle Aged
dc.subject.mesh	Neurogranin
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Transcriptome
dc.title	Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2021-12-01T09:50:15Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	10
utslib.citation.issue	4

Abstract:

Alzheimer's disease is a progressive, devastating, and irreversible brain disorder that, day by day, destroys memory skills and social behavior. Despite this, the number of known genes suitable for discriminating between AD patients is insufficient. Among the genes potentially involved in the development of AD, there are the chitinase-like proteins (CLPs) CHI3L1, CHI3L2, and CHID1. The genes of the first two have been extensively investigated while, on the contrary, little information is available on CHID1. In this manuscript, we conducted transcriptome meta-analysis on an extensive sample of brains of healthy control subjects (n = 1849) (NDHC) and brains of AD patients (n = 1170) in order to demonstrate CHID1 involvement. Our analysis revealed an inverse correlation between the brain CHID1 expression levels and the age of NDHC subjects. Significant differences were highlighted comparing CHID1 expression of NDHC subjects and AD patients. Exclusive in AD patients, the CHID1 expression levels were correlated positively to calcium-binding adapter molecule 1 (IBA1) levels. Furthermore, both in NDHC and in AD patient's brains, the CHID1 expression levels were directly correlated with calbindin 1 (CALB1) and neurogranin (NRGN). According to brain regions, correlation differences were shown between the expression levels of CHID1 in prefrontal, frontal, occipital, cerebellum, temporal, and limbic system. Sex-related differences were only highlighted in NDHC. CHID1 represents a new chitinase potentially involved in the principal processes underlying Alzheimer's disease.

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http://hdl.handle.net/10453/151999