Targeting and dissolution characteristics of bone forming and antibacterial drugs by harnessing the structure of microspherical shells from coral beach sand

Chou, J; Ben-Nissan, B; Green, DW; Valenzuela, SM; Kohan, L

Targeting and dissolution characteristics of bone forming and antibacterial drugs by harnessing the structure of microspherical shells from coral beach sand

Chou, J

Ben-Nissan, B Green, DW Valenzuela, SM

Kohan, L

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Publication Type:: Journal Article
Citation:: Advanced Engineering Materials, 2011, 13 (1-2), pp. 93 - 99
Issue Date:: 2011-02-01

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Field	Value	Language
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.contributor.author	Green, DW	en_US
dc.contributor.author	Valenzuela, SM https://orcid.org/0000-0001-5934-6047	en_US
dc.contributor.author	Kohan, L	en_US
dc.date.issued	2011-02-01	en_US
dc.identifier.citation	Advanced Engineering Materials, 2011, 13 (1-2), pp. 93 - 99	en_US
dc.identifier.issn	1438-1656	en_US
dc.identifier.uri	http://hdl.handle.net/10453/15257
dc.description.abstract	Pharmaceutical drugs for the treatment of metabolic bone diseases lead to a number of side effects due to the their uncontrollable dispersion throughout the body.1 Therefore, many groups directed their research to develop devices that are targeted to specific organs or tissues and release the encapsulated drug in a highly regulated way.2-7 The development of completely resorbable bone-filling biomaterials delivering drugs would offer a therapeutic approach of drug release and bone augmentation in a simple one-step process.8-11 The biomaterials selected needs custom designs, to control the quantity and the duration of drug release and at the same time inducing desirable host cell responses and preventing bacterial infection.12-15 Current synthetic biomaterials produced as drug delivery microspheres due to production difficulties contain not very well designed interconnected pores and fail to fill these pertinent requirements. Turning directly to nature such as marine structures for inventive solutions can help to solve these problems due to their structure, chemistry and architecture and their unique designs.16-20 We demonstrate -for the first time- the potential of unique coral shells with specific microspherical structure and highly organised interconnected intra-pore designs to offer a number of desired functions for targeted delivery of Bisphosphonate (BP) (paminodrate) and an antibiotic (Gentamicin) for bone regeneration, repair and preventive antibacterial slow drug delivery. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.	en_US
dc.relation.ispartof	Advanced Engineering Materials	en_US
dc.relation.isbasedon	10.1002/adem.201000208	en_US
dc.subject.classification	Materials	en_US
dc.title	Targeting and dissolution characteristics of bone forming and antibacterial drugs by harnessing the structure of microspherical shells from coral beach sand	en_US
dc.type	Journal Article
utslib.citation.volume	1-2	en_US
utslib.citation.volume	13	en_US
utslib.for	0912 Materials Engineering	en_US
dc.location.activity	WOS:000287044300022	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.issue	1-2	en_US
pubs.publication-status	Published	en_US
pubs.volume	13	en_US

Abstract:

Pharmaceutical drugs for the treatment of metabolic bone diseases lead to a number of side effects due to the their uncontrollable dispersion throughout the body.1 Therefore, many groups directed their research to develop devices that are targeted to specific organs or tissues and release the encapsulated drug in a highly regulated way.2-7 The development of completely resorbable bone-filling biomaterials delivering drugs would offer a therapeutic approach of drug release and bone augmentation in a simple one-step process.8-11 The biomaterials selected needs custom designs, to control the quantity and the duration of drug release and at the same time inducing desirable host cell responses and preventing bacterial infection.12-15 Current synthetic biomaterials produced as drug delivery microspheres due to production difficulties contain not very well designed interconnected pores and fail to fill these pertinent requirements. Turning directly to nature such as marine structures for inventive solutions can help to solve these problems due to their structure, chemistry and architecture and their unique designs.16-20 We demonstrate -for the first time- the potential of unique coral shells with specific microspherical structure and highly organised interconnected intra-pore designs to offer a number of desired functions for targeted delivery of Bisphosphonate (BP) (paminodrate) and an antibiotic (Gentamicin) for bone regeneration, repair and preventive antibacterial slow drug delivery. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/15257