Nanos gigantium humeris insidentes: old papers informing new research into Toxoplasma gondii.

Lodoen, MB; Smith, NC; Soldati-Favre, D; Ferguson, DJP; van Dooren, GG

Nanos gigantium humeris insidentes: old papers informing new research into Toxoplasma gondii.

Lodoen, MB Smith, NC Soldati-Favre, D Ferguson, DJP van Dooren, GG

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Int J Parasitol, 2021, 51, (13-14), pp. 1193-1212
Issue Date:: 2021-12

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Field	Value	Language
dc.contributor.author	Lodoen, MB
dc.contributor.author	Smith, NC
dc.contributor.author	Soldati-Favre, D
dc.contributor.author	Ferguson, DJP
dc.contributor.author	van Dooren, GG
dc.date.accessioned	2022-01-10T06:11:34Z
dc.date.available	2021-10-19
dc.date.available	2022-01-10T06:11:34Z
dc.date.issued	2021-12
dc.identifier.citation	Int J Parasitol, 2021, 51, (13-14), pp. 1193-1212
dc.identifier.issn	0020-7519
dc.identifier.issn	1879-0135
dc.identifier.uri	http://hdl.handle.net/10453/152877
dc.description.abstract	Since Nicolle, Manceaux and Splendore first described Toxoplasma gondii as a parasite of rodents and rabbits in the early 20th century, a diverse and vigorous research community has been built around studying this fascinating intracellular parasite. In addition to its importance as a pathogen of humans, livestock and wildlife, modern researchers are attracted to T. gondii as a facile experimental system to study many aspects of evolutionary biology, cellular biology, host-microbe interactions, and host immunity. For new researchers entering the field, the extensive literature describing the biology of the parasite, and the interactions with its host, can be daunting. In this review, we examine four foundational studies that describe various aspects of T. gondii biology, presenting a 'journal club'-style analysis of each. We have chosen a paper that established the beguiling life cycle of the parasite (Hutchison et al., 1971), a paper that described key features of its cellular biology that the parasite shares with related organisms (Gustafson et al., 1954), a paper that characterised the origin of the unique compartment in which the parasite resides within host cells (Jones and Hirsch, 1972), and a paper that established a key mechanism in the host immune response to parasite infection (Pfefferkorn, 1984). These interesting and far-reaching studies set the stage for subsequent research into numerous facets of parasite biology. As well as providing new researchers with an entry point into the literature surrounding the parasite, revisiting these studies can remind us of the roots of our discipline, how far we have come, and the new directions in which we might head.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1128911
dc.relation.ispartof	Int J Parasitol
dc.relation.isbasedon	10.1016/j.ijpara.2021.10.004
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0605 Microbiology, 0608 Zoology, 0707 Veterinary Sciences
dc.subject.classification	Mycology & Parasitology
dc.title	Nanos gigantium humeris insidentes: old papers informing new research into Toxoplasma gondii.
dc.type	Journal Article
utslib.citation.volume	51
utslib.location.activity	England
utslib.for	0605 Microbiology
utslib.for	0608 Zoology
utslib.for	0707 Veterinary Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access	*
dc.date.updated	2022-01-10T06:11:32Z
pubs.issue	13-14
pubs.publication-status	Published
pubs.volume	51
utslib.citation.issue	13-14

Abstract:

Since Nicolle, Manceaux and Splendore first described Toxoplasma gondii as a parasite of rodents and rabbits in the early 20th century, a diverse and vigorous research community has been built around studying this fascinating intracellular parasite. In addition to its importance as a pathogen of humans, livestock and wildlife, modern researchers are attracted to T. gondii as a facile experimental system to study many aspects of evolutionary biology, cellular biology, host-microbe interactions, and host immunity. For new researchers entering the field, the extensive literature describing the biology of the parasite, and the interactions with its host, can be daunting. In this review, we examine four foundational studies that describe various aspects of T. gondii biology, presenting a 'journal club'-style analysis of each. We have chosen a paper that established the beguiling life cycle of the parasite (Hutchison et al., 1971), a paper that described key features of its cellular biology that the parasite shares with related organisms (Gustafson et al., 1954), a paper that characterised the origin of the unique compartment in which the parasite resides within host cells (Jones and Hirsch, 1972), and a paper that established a key mechanism in the host immune response to parasite infection (Pfefferkorn, 1984). These interesting and far-reaching studies set the stage for subsequent research into numerous facets of parasite biology. As well as providing new researchers with an entry point into the literature surrounding the parasite, revisiting these studies can remind us of the roots of our discipline, how far we have come, and the new directions in which we might head.

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http://hdl.handle.net/10453/152877