Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Dhanjal, DS; Sharma, P; Mehta, M; Tambuwala, MM; Prasher, P; Paudel, KR; Liu, G; Shukla, SD; Hansbro, PM; Chellappan, DK; Dua, K; Satija, S

Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases

Dhanjal, DS Sharma, P Mehta, M Tambuwala, MM Prasher, P Paudel, KR Liu, G

Shukla, SD Hansbro, PM Chellappan, DK Dua, K Satija, S

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Publisher:: Future Science Ltd
Publication Type:: Journal Article
Citation:: Future Medicinal Chemistry

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Field	Value	Language
dc.contributor.author	Dhanjal, DS
dc.contributor.author	Sharma, P
dc.contributor.author	Mehta, M
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Prasher, P
dc.contributor.author	Paudel, KR
dc.contributor.author	Liu, G https://orcid.org/0000-0002-0489-2638
dc.contributor.author	Shukla, SD
dc.contributor.author	Hansbro, PM
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K
dc.contributor.author	Satija, S
dc.date.accessioned	2022-01-13T23:15:31Z
dc.date.available	2022-01-13T23:15:31Z
dc.identifier.citation	Future Medicinal Chemistry
dc.identifier.issn	1756-8919
dc.identifier.issn	1756-8927
dc.identifier.uri	http://hdl.handle.net/10453/153080
dc.description.abstract	<jats:p> Chronic respiratory disorders (CRDs) affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods. </jats:p>
dc.language	en
dc.publisher	Future Science Ltd
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation.ispartof	Future Medicinal Chemistry
dc.relation.isbasedon	10.4155/fmc-2021-0081
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights	Open access This work is licensed under the Creative Commons Attribution4.0 License. To view a copy of this license, visit http://creativecomm ons.org/licenses/by/4.0/
dc.subject	0304 Medicinal and Biomolecular Chemistry, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.title	Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases
dc.type	Journal Article
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	recently_added	*
dc.date.updated	2022-01-13T23:15:28Z
pubs.publication-status	Published online

Abstract:

Chronic respiratory disorders (CRDs) affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

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http://hdl.handle.net/10453/153080