Blood-Spinal Cord Barrier: Its Role in Spinal Disorders and Emerging Therapeutic Strategies

Chopra, N; Menounos, S; Choi, JP; Hansbro, PM; Diwan, AD; Das, A

Blood-Spinal Cord Barrier: Its Role in Spinal Disorders and Emerging Therapeutic Strategies

Chopra, N Menounos, S Choi, JP Hansbro, PM Diwan, AD Das, A

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: NeuroSci, 2021, 3, (1), pp. 1-27
Issue Date:: 2021-12-21

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Field	Value	Language
dc.contributor.author	Chopra, N
dc.contributor.author	Menounos, S
dc.contributor.author	Choi, JP
dc.contributor.author	Hansbro, PM
dc.contributor.author	Diwan, AD
dc.contributor.author	Das, A
dc.date.accessioned	2022-01-17T03:44:30Z
dc.date.available	2022-01-17T03:44:30Z
dc.date.issued	2021-12-21
dc.identifier.citation	NeuroSci, 2021, 3, (1), pp. 1-27
dc.identifier.issn	2673-4087
dc.identifier.issn	2673-4087
dc.identifier.uri	http://hdl.handle.net/10453/153207
dc.description.abstract	<jats:p>The blood-spinal cord barrier (BSCB) has been long thought of as a functional equivalent to the blood-brain barrier (BBB), restricting blood flow into the spinal cord. The spinal cord is supported by various disc tissues that provide agility and has different local immune responses compared to the brain. Though physiologically, structural components of the BSCB and BBB share many similarities, the clinical landscape significantly differs. Thus, it is crucial to understand the composition of BSCB and also to establish the cause–effect relationship with aberrations and spinal cord dysfunctions. Here, we provide a descriptive analysis of the anatomy, current techniques to assess the impairment of BSCB, associated risk factors and impact of spinal disorders such as spinal cord injury (SCI), amyotrophic lateral sclerosis (ALS), peripheral nerve injury (PNI), ischemia reperfusion injury (IRI), degenerative cervical myelopathy (DCM), multiple sclerosis (MS), spinal cavernous malformations (SCM) and cancer on BSCB dysfunction. Along with diagnostic and mechanistic analyses, we also provide an up-to-date account of available therapeutic options for BSCB repair. We emphasize the need to address BSCB as an individual entity and direct future research towards it.</jats:p>
dc.language	en
dc.publisher	MDPI AG
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1175134
dc.relation.ispartof	NeuroSci
dc.relation.isbasedon	10.3390/neurosci3010001
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Blood-Spinal Cord Barrier: Its Role in Spinal Disorders and Emerging Therapeutic Strategies
dc.type	Journal Article
utslib.citation.volume	3
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2022-01-17T03:44:29Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	3
utslib.citation.issue	1

Abstract:

The blood-spinal cord barrier (BSCB) has been long thought of as a functional equivalent to the blood-brain barrier (BBB), restricting blood flow into the spinal cord. The spinal cord is supported by various disc tissues that provide agility and has different local immune responses compared to the brain. Though physiologically, structural components of the BSCB and BBB share many similarities, the clinical landscape significantly differs. Thus, it is crucial to understand the composition of BSCB and also to establish the cause–effect relationship with aberrations and spinal cord dysfunctions. Here, we provide a descriptive analysis of the anatomy, current techniques to assess the impairment of BSCB, associated risk factors and impact of spinal disorders such as spinal cord injury (SCI), amyotrophic lateral sclerosis (ALS), peripheral nerve injury (PNI), ischemia reperfusion injury (IRI), degenerative cervical myelopathy (DCM), multiple sclerosis (MS), spinal cavernous malformations (SCM) and cancer on BSCB dysfunction. Along with diagnostic and mechanistic analyses, we also provide an up-to-date account of available therapeutic options for BSCB repair. We emphasize the need to address BSCB as an individual entity and direct future research towards it.

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http://hdl.handle.net/10453/153207