Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging in Biology.

Doble, PA; de Vega, RG; Bishop, DP; Hare, DJ; Clases, D

Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging in Biology.

Doble, PA de Vega, RG Bishop, DP Hare, DJ Clases, D

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Publisher:: American Chemical Society
Publication Type:: Journal Article
Citation:: Chemical Reviews, 2021, 121, (19), pp. 11769-11822
Issue Date:: 2021-10-13

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Field	Value	Language
dc.contributor.author	Doble, PA
dc.contributor.author	de Vega, RG
dc.contributor.author	Bishop, DP
dc.contributor.author	Hare, DJ
dc.contributor.author	Clases, D https://orcid.org/0000-0003-3880-9385
dc.date.accessioned	2022-01-18T23:11:51Z
dc.date.available	2022-01-18T23:11:51Z
dc.date.issued	2021-10-13
dc.identifier.citation	Chemical Reviews, 2021, 121, (19), pp. 11769-11822
dc.identifier.issn	0009-2665
dc.identifier.issn	1520-6890
dc.identifier.uri	http://hdl.handle.net/10453/153294
dc.description.abstract	Elemental imaging gives insight into the fundamental chemical makeup of living organisms. Every cell on Earth is comprised of a complex and dynamic mixture of the chemical elements that define structure and function. Many disease states feature a disturbance in elemental homeostasis, and understanding how, and most importantly where, has driven the development of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) as the principal elemental imaging technique for biologists. This review provides an outline of ICP-MS technology, laser ablation cell designs, imaging workflows, and methods of quantification. Detailed examples of imaging applications including analyses of cancers, elemental uptake and accumulation, plant bioimaging, nanomaterials in the environment, and exposure science and neuroscience are presented and discussed. Recent incorporation of immunohistochemical workflows for imaging biomolecules, complementary and multimodal imaging techniques, and image processing methods is also reviewed.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American Chemical Society
dc.relation	http://purl.org/au-research/grants/arc/DE180100194
dc.relation	http://purl.org/au-research/grants/arc/DP190102361
dc.relation	US Department of Health and Human Services1R21AR072950-01A1
dc.relation	German Research Foundation417283954
dc.relation.ispartof	Chemical Reviews
dc.relation.isbasedon	10.1021/acs.chemrev.0c01219
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Chemical Reviews, copyright © American Chemical Society after peer review. To access the final edited and published work see http://doi.org/10.1021/acs.chemrev.0c01219
dc.subject	03 Chemical Sciences
dc.subject.classification	General Chemistry
dc.title	Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging in Biology.
dc.type	Journal Article
utslib.citation.volume	121
utslib.location.activity	United States
utslib.for	03 Chemical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-01-18T23:11:38Z
pubs.issue	19
pubs.publication-status	Published
pubs.volume	121
utslib.citation.issue	19

Abstract:

Elemental imaging gives insight into the fundamental chemical makeup of living organisms. Every cell on Earth is comprised of a complex and dynamic mixture of the chemical elements that define structure and function. Many disease states feature a disturbance in elemental homeostasis, and understanding how, and most importantly where, has driven the development of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) as the principal elemental imaging technique for biologists. This review provides an outline of ICP-MS technology, laser ablation cell designs, imaging workflows, and methods of quantification. Detailed examples of imaging applications including analyses of cancers, elemental uptake and accumulation, plant bioimaging, nanomaterials in the environment, and exposure science and neuroscience are presented and discussed. Recent incorporation of immunohistochemical workflows for imaging biomolecules, complementary and multimodal imaging techniques, and image processing methods is also reviewed.

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http://hdl.handle.net/10453/153294