Pew2: Open-Source Imaging Software for Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry.

Lockwood, TE; Westerhausen, MT; Doble, PA

Pew2: Open-Source Imaging Software for Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry.

Lockwood, TE Westerhausen, MT Doble, PA

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Publisher:: American Chemical Society
Publication Type:: Journal Article
Citation:: Analytical Chemistry, 2021, 93, (30), pp. 10418-10423
Issue Date:: 2021-08-03

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Field	Value	Language
dc.contributor.author	Lockwood, TE
dc.contributor.author	Westerhausen, MT
dc.contributor.author	Doble, PA
dc.date.accessioned	2022-01-18T23:32:11Z
dc.date.available	2022-01-18T23:32:11Z
dc.date.issued	2021-08-03
dc.identifier.citation	Analytical Chemistry, 2021, 93, (30), pp. 10418-10423
dc.identifier.issn	0003-2700
dc.identifier.issn	1520-6882
dc.identifier.uri	http://hdl.handle.net/10453/153300
dc.description.abstract	Open-sourced software is a key component of the mass spectrometry imaging field, where transparency in data processing is vital. Imaging of trace elements and immunohistochemically labeled biomolecules in tissue sections is typically performed using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). However, efficient and facile processing of images is hampered by a lack of verifiable and user-friendly software that supports multiple LA-ICP-MS platforms. In this technical note, we introduce Pew2, a LA-ICP-MS specific and feature-rich open-source image processing software that is compatible with common ICP-MS vendors. Pew2 is designed to be fast and easy to use and adheres to modern visualization philosophies to maximize productivity and to minimize data interpretation errors and image anomalies.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American Chemical Society
dc.relation	http://purl.org/au-research/grants/arc/DP190102361
dc.relation.ispartof	Analytical Chemistry
dc.relation.isbasedon	10.1021/acs.analchem.1c02138
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Analytical Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see http://doi.org/10.1021/acs.analchem.1c02138
dc.subject	0301 Analytical Chemistry, 0399 Other Chemical Sciences
dc.subject.classification	Analytical Chemistry
dc.subject.mesh	Laser Therapy
dc.subject.mesh	Mass Spectrometry
dc.subject.mesh	Software
dc.subject.mesh	Spectrum Analysis
dc.subject.mesh	Trace Elements
dc.subject.mesh	Laser Therapy
dc.subject.mesh	Mass Spectrometry
dc.subject.mesh	Software
dc.subject.mesh	Spectrum Analysis
dc.subject.mesh	Trace Elements
dc.subject.mesh	Trace Elements
dc.subject.mesh	Spectrum Analysis
dc.subject.mesh	Software
dc.subject.mesh	Mass Spectrometry
dc.subject.mesh	Laser Therapy
dc.title	Pew2: Open-Source Imaging Software for Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry.
dc.type	Journal Article
utslib.citation.volume	93
utslib.location.activity	United States
utslib.for	0301 Analytical Chemistry
utslib.for	0399 Other Chemical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-01-18T23:32:07Z
pubs.issue	30
pubs.publication-status	Published
pubs.volume	93
utslib.citation.issue	30

Abstract:

Open-sourced software is a key component of the mass spectrometry imaging field, where transparency in data processing is vital. Imaging of trace elements and immunohistochemically labeled biomolecules in tissue sections is typically performed using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). However, efficient and facile processing of images is hampered by a lack of verifiable and user-friendly software that supports multiple LA-ICP-MS platforms. In this technical note, we introduce Pew2, a LA-ICP-MS specific and feature-rich open-source image processing software that is compatible with common ICP-MS vendors. Pew2 is designed to be fast and easy to use and adheres to modern visualization philosophies to maximize productivity and to minimize data interpretation errors and image anomalies.

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http://hdl.handle.net/10453/153300